DUGi

Asymmetric epoxidation with H2O2 by manipulating the electronic properties of non-heme iron catalysts

http://dugi.udg.edu/item/http:@@@@hdl.handle.net@@10256@@10022

A non-heme iron complex that catalyzes highly enantioselective epoxidation of olefins with H2O2 is described. Improvement of enantiomeric excesses is attained by the use of catalytic amounts of carboxylic acid additives. Electronic effects imposed by the ligand on the iron center are shown to synergistically cooperate with catalytic amounts of carboxylic acids in promoting efficient O-O cleavage and creating highly chemo-and enantioselective epoxidizing species which provide a broad range of epoxides in synthetically valuable yields and short reaction times

We acknowledge financial support from European Research Council (ERC-2009-StG-239910), MINECO of Spain (CTQ2012-37420-C02-01/BQU, Consolider-Ingenio CSD2010-00065), and the Catalan DIUE of the Generalitat de Catalunya (2009SGR637). J.Ll.-F. thanks MICINN for a RyC contract. X.R. and M.C. acknowledge ICREA-Academia awards. X.R. is grateful for financial support from INNPLAN-TA Project No. IPN-2011-0059-PCT-42000-ACT1. I.G.-B. thanks the European Community for an IOF Marie Curie fellowship. We acknowledge STRs from UdG for technical support

info:eu-repo/grantAgreement/MINECO//CTQ2012-37420-C02-01/ES/DISE脩O BIOINSPIRADO DE CATALIZADORES PARA LA OXIDACION DE ENLACES C-H, C=C Y AGUA/

American Chemical Society (ACS)