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The iron (II) complex [Fe(CF3SO3)2(mcp)] as a convenient, readily available catalyst for the selective oxidation of methylenic sites in alkanes

The efficient and selective oxidation of secondary C-H sites of alkanes is achieved by using low catalyst loadings of a non-expensive, readily available iron catalyst [Fe(II)(CF3SO3)2(mcp)], {Fe-mcp, [mcp=N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine]}, and hydrogen peroxide (H2O2) as oxidant, via a simple reaction protocol. Natural products are selectively oxidized and isolated in synthetically amenable yields. The easy access to large quantities of the catalyst and the simplicity of the C-H oxidation procedure make this system a particularly convenient tool to carry out alkane C-H oxidation reactions on the preparative scale, and in short reaction times

We would like to thank European Research Foundation for Project ERC-2009-StG-239910, MICINN for projects CTQ2012-37420-C02-01/BQU and CSD2010-00065. Generalitat de Catalunya for an ICREA Academia Award (X. R. and M. C.) and PhD grant (M. Canta). X. R. thanks financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1

© Advanced Synthesis and Catalysis, 2014, vol. 356, p. 818-830

Wiley-VCH Verlag

Author: Canta i Roldós, Mercè
Font Gimbernat, David
Gómez Martín, Laura
Ribas Salamaña, Xavi
Costas Salgueiro, Miquel
Date: 2014
Abstract: The efficient and selective oxidation of secondary C-H sites of alkanes is achieved by using low catalyst loadings of a non-expensive, readily available iron catalyst [Fe(II)(CF3SO3)2(mcp)], {Fe-mcp, [mcp=N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine]}, and hydrogen peroxide (H2O2) as oxidant, via a simple reaction protocol. Natural products are selectively oxidized and isolated in synthetically amenable yields. The easy access to large quantities of the catalyst and the simplicity of the C-H oxidation procedure make this system a particularly convenient tool to carry out alkane C-H oxidation reactions on the preparative scale, and in short reaction times
We would like to thank European Research Foundation for Project ERC-2009-StG-239910, MICINN for projects CTQ2012-37420-C02-01/BQU and CSD2010-00065. Generalitat de Catalunya for an ICREA Academia Award (X. R. and M. C.) and PhD grant (M. Canta). X. R. thanks financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1
Format: application/pdf
ISSN: 1615-4150 (versió paper)
1615-4169 (versió electrònica)
Document access: http://hdl.handle.net/10256/10178
Language: eng
Publisher: Wiley-VCH Verlag
Collection: MINECO/PN 2013-2015/CTQ2012-37420-C02-01
MICINN/PN 2010-2016/CSD2010-00065
MICINN/PN 2011/INP-2011-0059-PCT-420000
Reproducció digital del document publicat a: http://dx.doi.org/10.1002/adsc.201300923
Articles publicats (D-Q)
info:eu-repo/grantAgreement/EC/FP7/239910
Is part of: © Advanced Synthesis and Catalysis, 2014, vol. 356, p. 818-830
Rights: Tots els drets reservats
Subject: Oxidació
Oxidation
Catàlisi
Catalysis
Aigua oxigenada
Hydrogen peroxide
Ferro
Iron
Productes naturals
Natural products
Title: The iron (II) complex [Fe(CF3SO3)2(mcp)] as a convenient, readily available catalyst for the selective oxidation of methylenic sites in alkanes
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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