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Ministerio de Ciencia e Innovación (Espanya) | |
Gómez MartÃn, Laura
Canta i Roldós, Mercè Font Gimbernat, David Prat Casellas, Irene Ribas Salamaña, Xavi Costas Salgueiro, Miquel |
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2013 | |
Selective oxidation of alkyl C-H groups constitutes one of the highest challenges in organic synthesis. In this work, we show that mononuclear iron coordination complexes Lambda-[Fe(CF3SO3)(2)((S,S,R)-MCPP)] (Lambda-1P), Delta-[Fe(CF3SO3)(2)((R,R,R)-MCPP)] (Delta-1P), Lambda-[Fe(CF3SO3)(2)((S,S,R)-BPBPP)] (Lambda-2P), and Delta-[Fe(CF3SO3)(2)((R,R,R)-BPBPP)] (Delta-2P) catalyze the fast, efficient, and selective oxidation of nonactivated alkyl C-H groups employing H2O2 as terminal oxidant. These complexes are based on tetradentate N-based ligands and contain iron centers embedded in highly structured coordination sites defined by two bulky 4,5-pinenopyridine donor ligands, a chiral diamine ligand backbone, and chirality at the metal (Lambda or Delta). X-ray diffraction analysis shows that in Lambda-1P and Lambda-2P the pinene rings create cavity-like structures that isolate the iron site. The efficiency and regioselectivity in catalytic C-H oxidation reactions of these structurally rich complexes has been compared with those of Lambda-[Fe(CF3SO3)(2)((S,S)-MCP)] (Lambda-1), Lambda-[Fe(CF3SO3)(2)((S,S)-BPBP)] (Lambda-2), Delta-[Fe(CF3SO3)(2)((R,R)-BPBP)] (Delta-2), Lambda-[Fe(CH3CN)(2)((S,S)-BPBP)] (SbF6)(2) (Lambda-2SbF(6)), and Delta-[Fe(CH3CN)(2)((R,R)-BPBP)](SbF6)(2) (Delta-2SbF(6)), which lack the steric bulk introduced by the pinene rings. Cavity-containing complexes Lambda-1P and Lambda-2P exhibit enhanced activity in comparison with Delta-1P, Delta-2P, Lambda-1, Lambda-2, and Lambda-2SbF(6). The regioselectivity exhibited by catalysts Lambda-1P, Lambda-2P, Delta-1P, and Delta-2P in the C-H oxidation of simple organic molecules can be predicted on the basis of the innate properties of the distinct C-H groups of the substrate. However, in specific complex organic molecules where oxidation of multiple C-H sites is competitive, the highly elaborate structure of the catalysts allows modulation of C-H regioselectivity between the oxidation of tertiary and secondary C-H groups and also among multiple methylene sites, providing oxidation products in synthetically valuable yields. These selectivities complement those accomplished with structurally simpler oxidants, including non-heme iron catalysts Lambda-2 and Lambda-2SbF(6) We thank the European Research Foundation for Starting Grant Project ERC-2009-StG-239910, MICINN for project CTQ2009-08464 and a Ph.D. grant (I.P.), and the Generalitat de Catalunya for a Ph.D. grant (M. Canta). X.R. thanks financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1. M.C. and X.R. thank ICREA Academia Awards |
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application/pdf | |
http://hdl.handle.net/10256/10179 | |
eng | |
American Chemical Society (ACS) | |
info:eu-repo/semantics/altIdentifier/doi/10.1021/jo302196q info:eu-repo/semantics/altIdentifier/issn/0022-3263 info:eu-repo/semantics/altIdentifier/eissn/1520-6904 MICINN/PN 2010-2012/CTQ2009-08464 MICINN/PN 2011/INP-2011-0059-PCT-420000 info:eu-repo/grantAgreement/EC/FP7/239910/EU/Bio-inspired Design of Catalysts for Selective Oxidations of C-H and C=C Bonds/BIDECASEOX |
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Tots els drets reservats | |
Oxidació
Oxidation Catà lisi Catalysis Aigua oxigenada Hydrogen peroxide Ferro Iron |
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Regioselective oxidation of nonactivated alkyl C-H groups using highly structured non-heme iron catalysts | |
info:eu-repo/semantics/article | |
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