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Ministerio de Ciencia e InnovaciĂłn (Espanya) | |
Poater Teixidor, Albert
Vummaleti, Sai Vikrama Chaitanya Cavallo, Luigi |
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2013 | |
Density functional theory calculations have been used to investigate the catalytic role of nickel(0) in the decarbonylative addition of phthalimides to alkynes. According to Kurahashi et al. the plausible reaction mechanism involves a nucleophilic attack of nickel at an imide group, giving a six-membered metallacycle, followed by a decarbonylation and insertion of an alkyne leading to a seven-membered metallacycle. Finally a reductive elimination process produces the desired product and regenerates the nickel(0) catalyst. In this paper, we present a full description of the complete reaction pathway along with possible alternative pathways, which are predicted to display higher upper barriers. Our computational results substantially confirm the proposed mechanism, offering a detailed geometrical and energetical understanding of all the elementary steps A.P. and L.C. thank the HPC team of Enea for using the ENEA-GRID and the HPC facilities CRESCO in Portici (Italy) for access to remarkable computational resources. A.P. thanks the Spanish MICINN for a Ramon y Cajal contract (RYC-2009-05226), European Commission for a Career Integration Grant (CIG09-GA-2011-293900), and Generalitat de Catalunya (2012BE100824) |
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application/pdf | |
http://hdl.handle.net/10256/10340 | |
eng | |
American Chemical Society (ACS) | |
info:eu-repo/semantics/altIdentifier/doi/10.1021/om400693v info:eu-repo/semantics/altIdentifier/issn/0276-7333 info:eu-repo/semantics/altIdentifier/eissn/1520-6041 info:eu-repo/grantAgreement/MICINN//RYC-2009-05226/ES/RYC-2009-05226/ info:eu-repo/grantAgreement/EC/FP7/293900/EU/Ab initio Statics and Molecular Dynamics Simulation of Olefin Metathesis Catalysts for pharmacological purposes/COMPUTEDRUG |
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Tots els drets reservats | |
Funcional de densitat, Teoria del
Density functionals Catalitzadors de nĂquel Nickel catalysts |
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Catalytic role of nickel in the decarbonylative addition of phthalimides to alkynes | |
info:eu-repo/semantics/article | |
DUGiDocs |