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How can alcohol production be improved in carboxydotrophic clostridia?

Clostridia are well-known organisms within the scientific community, and many aspects of their life cycle have been studied. Autotrophic strains are especially interesting as microbial cell factories for industrial purposes. Carboxydotrophic clostridia can use CO2/H2 and/or CO as their only carbon and reducing power sources, and they produce alcohols and acids. Both products can be used as either biofuels or feedstock chemicals for many industrial processes, confirming the control of carboxydotrophic clostridia metabolism as one of the most profitable scientific ambitions to be explored. Here, we review the current state of research on alcohol production by carboxydotrophic clostridia, including a comprehensive overview of their metabolic pathways and the key experimental variables that govern alcohol production. Additionally, the genetic and genomic tools for selective and enhanced solvent production, which are currently under intense development, are discussed. In this context, this review covers the main genetic engineering methods that have been utilized to improve the capabilities of solventogenic carboxydotrophic bacteria

The review was prepared within the framework of the fellowship 2013 FI-DGR from Catalan Government and projects Best-Energy CTQ2011-23632 and CTM2013-43454-R from Spanish Ministry. LEQUIA and [BA are recognized as consolidated research groups by the Catalan Government (2014-SGR-1168 and 2014-SGR-2016). Ramon Ganigue gratefully acknowledges support from the Beatriu de Pinos Fellowship (BP-2011-B) and FP7 Marie Curie Career Integration Grants (PCIG13-GA-2013-618593

© Process Biochemistry, 2015, vol. 50, núm. 7, p. 1047-1055

Elsevier

Author: Ramió Pujol, Sara
Ganigué Pagès, Ramon
Bañeras Vives, Lluís
Colprim Galceran, Jesús
Date: 2015 April 3
Abstract: Clostridia are well-known organisms within the scientific community, and many aspects of their life cycle have been studied. Autotrophic strains are especially interesting as microbial cell factories for industrial purposes. Carboxydotrophic clostridia can use CO2/H2 and/or CO as their only carbon and reducing power sources, and they produce alcohols and acids. Both products can be used as either biofuels or feedstock chemicals for many industrial processes, confirming the control of carboxydotrophic clostridia metabolism as one of the most profitable scientific ambitions to be explored. Here, we review the current state of research on alcohol production by carboxydotrophic clostridia, including a comprehensive overview of their metabolic pathways and the key experimental variables that govern alcohol production. Additionally, the genetic and genomic tools for selective and enhanced solvent production, which are currently under intense development, are discussed. In this context, this review covers the main genetic engineering methods that have been utilized to improve the capabilities of solventogenic carboxydotrophic bacteria
The review was prepared within the framework of the fellowship 2013 FI-DGR from Catalan Government and projects Best-Energy CTQ2011-23632 and CTM2013-43454-R from Spanish Ministry. LEQUIA and [BA are recognized as consolidated research groups by the Catalan Government (2014-SGR-1168 and 2014-SGR-2016). Ramon Ganigue gratefully acknowledges support from the Beatriu de Pinos Fellowship (BP-2011-B) and FP7 Marie Curie Career Integration Grants (PCIG13-GA-2013-618593
Format: application/pdf
ISSN: 1359-5113
Document access: http://hdl.handle.net/10256/11327
Language: eng
Publisher: Elsevier
Collection: MINECO/PE 2014-2015/CTM2013-43454-R
MICINN/PN 2012-2014/CTQ2011-23632
AGAUR/2013 FI-DGR
Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.procbio.2015.03.019
Articles publicats (D-EQATA)
info:eu-repo/grantAgreement/EC/FP7/618593
Is part of: © Process Biochemistry, 2015, vol. 50, núm. 7, p. 1047-1055
Rights: Tots els drets reservats
Subject: Clostridi
Clostridium
Alcohol
Title: How can alcohol production be improved in carboxydotrophic clostridia?
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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