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Reliability of the ABC/2 Method in Determining Acute Infarct Volume

Background and Purpose: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. Methods: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. Results: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm 3 (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. Conclusions: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume

This work was supported in part by governments’ grants: From MEC TIN2010-21089-C03-01 and from Fondo de Investigaciones Sanitarias (FIS) grant (reference PI09/00596)

info:eu-repo/grantAgreement/MICINN//TIN2010-21089-C03-01/ES/CONTENIDO DIGITAL PARA JUEGOS SERIOS: CREACION, GESTION, RENDERIZADO E INTERACCION/

Wiley

Manager: Ministerio de Ciencia e Innovación (Espanya)
Author: Pedraza, S.
Puig Alcántara, Josep
Blasco Solà, Gerard
Daunis-i-Estadella, Pepus
Boada, Imma
Bardera i Reig, Antoni
Castellanos, María del Mar
Serena, Joaquín
Date: 2012
Abstract: Background and Purpose: Infarct volume is used as a surrogate outcome measure in clinical trials of therapies for acute ischemic stroke. ABC/2 is a fast volumetric method, but its accuracy remains to be determined. We aimed to study the accuracy and reproducibility of ABC/2 in determining acute infarct volume with diffusion-weighted imaging. Methods: We studied 86 consecutive patients with acute ischemic stroke. Three blinded observers determined volume with the ABC/2 method, and the results were compared with those of the manual planimetric method. Results: The ABC/2 technique overestimated infarct volume by a median false increase (variable ABC/2 volume minus planimetric volume) of 7.33 cm 3 (1.29, 22.170, representing a 162.56% increase over the value of the gold standard (variable ABC/2 volume over planimetric volume) (121.70, 248.52). In each method, the interrater reliability was excellent: the intraclass correlations were .992 and .985 for the ABC/2 technique and planimetric method, respectively. Conclusions: ABC/2 is volumetric method with clinical value but it consistently overestimates the real infarct volume
This work was supported in part by governments’ grants: From MEC TIN2010-21089-C03-01 and from Fondo de Investigaciones Sanitarias (FIS) grant (reference PI09/00596)
Format: application/pdf
Document access: http://hdl.handle.net/10256/11680
Language: eng
Publisher: Wiley
Collection: info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1552-6569.2011.00588.x
info:eu-repo/semantics/altIdentifier/issn/1051-2284
info:eu-repo/semantics/altIdentifier/issn/1051-2284
info:eu-repo/semantics/altIdentifier/eissn/1552-6569
Is part of: info:eu-repo/grantAgreement/MICINN//TIN2010-21089-C03-01/ES/CONTENIDO DIGITAL PARA JUEGOS SERIOS: CREACION, GESTION, RENDERIZADO E INTERACCION/
Rights: Tots els drets reservats
Subject: Isquèmia cerebral
Cerebral ischemia
Malalties cerebrovasculars
Cerebrovascular disease
Title: Reliability of the ABC/2 Method in Determining Acute Infarct Volume
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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