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Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine

The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans

This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)

© Applied and Environmental Microbiology, 2011, vol.77, núm. 16, p. 5813-5817

American Society for Microbiology

Author: Martínez Medina, Margarita
Garcia-Gil, L. J.
Barnich, Nicolas
Wieler, Lothar H.
Ewers, Christa
Date: 2011
Abstract: The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans
This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)
Format: application/pdf
ISSN: 0099-2240 (versió paper)
1098-5336 (versió electrònica)
0099-2240
Document access: http://hdl.handle.net/10256/11688
Language: eng
Publisher: American Society for Microbiology
Collection: MICINN/PN 2011-2013/SAF2010-15896
Reproducció digital del document publicat a: http://dx.doi.org/10.1128/AEM.02614-10
Articles publicats (D-B)
Is part of: © Applied and Environmental Microbiology, 2011, vol.77, núm. 16, p. 5813-5817
Rights: Tots els drets reservats
Subject: Intestins -- Inflamació
Inflammatory bowel diseases
Crohn, Malaltia de
Crohn’s disease
Infeccions per escheríchia coli
Escherichia coli infections
Title: Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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