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Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine

The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans

This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)

American Society for Microbiology

Director: Ministerio de Ciencia e Innovación (Espanya)
Autor: Martínez Medina, Margarita
Garcia-Gil, L. J.
Barnich, Nicolas
Wieler, Lothar H.
Ewers, Christa
Data: 2011
Resum: The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans
This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)
Format: application/pdf
Accés al document: http://hdl.handle.net/10256/11688
Llenguatge: eng
Editor: American Society for Microbiology
Col·lecció: info:eu-repo/semantics/altIdentifier/doi/10.1128/AEM.02614-10
info:eu-repo/semantics/altIdentifier/issn/0099-2240
info:eu-repo/semantics/altIdentifier/issn/0099-2240
info:eu-repo/semantics/altIdentifier/eissn/1098-5336
info:eu-repo/grantAgreement/MICINN//SAF2010-15896/ES/ESCHERICHIA COLI ADHERENTE INVASIVA (AIEC): PREVALENCIA EN OTRAS ENFERMEDADES INTESTINALES DISTINTAS DE CROHN Y DETERMINANTES GENICOS IMPLICADOS EN SU PATOGENICIDAD./
Drets: Tots els drets reservats
Matèria: Intestins -- Inflamació
Inflammatory bowel diseases
Crohn, Malaltia de
Crohn’s disease
Infeccions per escheríchia coli
Escherichia coli infections
Títol: Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

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