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Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes

The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator

This work was supported in part by the FEDER-CICYT under Grant DPI2008-06880-C03-01, Grant DPI2011-28112-C04-01, and Grant DPI2010-20764-C02, in part by the European Union Seventh Framework Programme (FP7/2007-2013) under Grant FP7-PEOPLE-2009-IEF Ref 252085, and in part by the Argentinian Government under Grant ANPCyT PICT-2011-0888, Grant CONICET PIP112-2011-00361, and Grant UNLP I164. The work of A. Revert was supported by the Spanish Ministry of Science and Innovation fellowship under Grant FPI BES- 2009-020327

info:eu-repo/grantAgreement/MICINN//DPI2008-06880-C03-01/ES/MODELADO MULTIESCALA EN BIOLOGIA DE SISTEMAS. APLICACION A LA MONITORIZACION, OPTIMIZACION Y CONTROL DE BIOPROCESOS./

Institute of Electrical and Electronics Engineers (IEEE)

Director: Ministerio de Educación y Ciencia (Espanya)
Ministerio de Ciencia e Innovación (Espanya)
Autor: Revert Tomás, Ana
Garelli, Fabricio
Picó i Marco, Jesús
Battista, Hernán de
Rossetti, Paolo
Vehí, Josep
Bondia, Jorge
Data: 5 agost 2013
Resum: The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator
This work was supported in part by the FEDER-CICYT under Grant DPI2008-06880-C03-01, Grant DPI2011-28112-C04-01, and Grant DPI2010-20764-C02, in part by the European Union Seventh Framework Programme (FP7/2007-2013) under Grant FP7-PEOPLE-2009-IEF Ref 252085, and in part by the Argentinian Government under Grant ANPCyT PICT-2011-0888, Grant CONICET PIP112-2011-00361, and Grant UNLP I164. The work of A. Revert was supported by the Spanish Ministry of Science and Innovation fellowship under Grant FPI BES- 2009-020327
Format: application/pdf
Accés al document: http://hdl.handle.net/10256/11732
Llenguatge: eng
Editor: Institute of Electrical and Electronics Engineers (IEEE)
Col·lecció: info:eu-repo/semantics/altIdentifier/doi/10.1109/TBME.2013.2247602
info:eu-repo/semantics/altIdentifier/issn/0018-9294
info:eu-repo/grantAgreement/MICINN//DPI2010-20764-C02-02/ES/NUEVAS ESTRATEGIAS DE CONTROL GLUCEMICO POSTPRANDIAL MEDIANTE TERAPIA CON BOMBA DE INSULINA EN DIABETES TIPO 1/
És part de: info:eu-repo/grantAgreement/MICINN//DPI2008-06880-C03-01/ES/MODELADO MULTIESCALA EN BIOLOGIA DE SISTEMAS. APLICACION A LA MONITORIZACION, OPTIMIZACION Y CONTROL DE BIOPROCESOS./
Drets: Tots els drets reservats
Matèria: Control intel·ligent
Intelligent control systems
Control automàtic
Automatic control
Hipoglucèmia
Hypoglycemia
Diabetis
Diabetes
Pàncrees artificial
Artificial pancreas
Títol: Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

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