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Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes

The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator

This work was supported in part by the FEDER-CICYT under Grant DPI2008-06880-C03-01, Grant DPI2011-28112-C04-01, and Grant DPI2010-20764-C02, in part by the European Union Seventh Framework Programme (FP7/2007-2013) under Grant FP7-PEOPLE-2009-IEF Ref 252085, and in part by the Argentinian Government under Grant ANPCyT PICT-2011-0888, Grant CONICET PIP112-2011-00361, and Grant UNLP I164. The work of A. Revert was supported by the Spanish Ministry of Science and Innovation fellowship under Grant FPI BES- 2009-020327

© IEEE Transactions on Biomedical Engineering, 2013, vol. 60, núm. 8, p. 2113-2122

Institute of Electrical and Electronics Engineers (IEEE)

Author: Revert Tomás, Ana
Garelli, Fabricio
Picó i Marco, Jesús
Battista, Hernán de
Rossetti, Paolo
Vehí, Josep
Bondía Company, Jorge
Date: 2013 August 5
Abstract: The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the artificial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator
This work was supported in part by the FEDER-CICYT under Grant DPI2008-06880-C03-01, Grant DPI2011-28112-C04-01, and Grant DPI2010-20764-C02, in part by the European Union Seventh Framework Programme (FP7/2007-2013) under Grant FP7-PEOPLE-2009-IEF Ref 252085, and in part by the Argentinian Government under Grant ANPCyT PICT-2011-0888, Grant CONICET PIP112-2011-00361, and Grant UNLP I164. The work of A. Revert was supported by the Spanish Ministry of Science and Innovation fellowship under Grant FPI BES- 2009-020327
Format: application/pdf
ISSN: 0018-9294
Document access: http://hdl.handle.net/10256/11732
Language: eng
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Collection: MEC/PN 2008-2011/DPI2008-06880-C03-01
MICINN/PN 2011-2013/DPI2010-20764-C02
Reproducció digital del document publicat a: http://dx.doi.org/10.1109/TBME.2013.2247602
Articles publicats (D-EEEiA)
Is part of: © IEEE Transactions on Biomedical Engineering, 2013, vol. 60, núm. 8, p. 2113-2122
Rights: Tots els drets reservats
Subject: Control intel·ligent
Intelligent control systems
Control automàtic
Automatic control
Hipoglucèmia
Hypoglycemia
Diabetis
Diabetes
Title: Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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