Item


Análisis de fármacos y disruptores endocrinos en peces y moluscos destinados al consumo humano

In recent years it has detected the presence of pharmaceuticals and endocrine disruptors in aquatic environments. These compounds may accumulate in marine organisms such as fish and shellfish if longZterm exposure and consumption of these organisms occurs could cause a risk to human health. With the main objective to assess this risk arises the European project "Priority environmental contaminants in seafood: safety assessment, impact and public perception" (ECsafeSEAFOOD) within which development has this work. It has analyzed samples of fish and shellfish for human consumption, mainly from different European regions, but have also included some samples of imported organisms. The compounds under study were diruptores endocrine compounds (EDCs) particularly triclosan, methylparaben, bisphenol A and TBEP and pharmacologically active compounds (PHACS) such as diazepam, sotalol, azithromycin, carbamazepine, diclofenac, citalopram, venlafaxine and sulfamethoxazole. Two samplings were conducted at different times of year and also the second one of the samples were steamed. The analysis of samples was performed using two analytical methods multiresidue. The protocol followed for EDCs is based on the use of QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe [fast, easy, economical, efficient, robust and secure]). for extraction and purification sample, while for PHACS pressurized extraction with solvents (PLE) followed by a purification step with gel chromatography (GPC) was use. In both cases the detection and quantification of samples end was performed by chromatography coupled to mass spectrometry (UHPLCZMS) liquid. The results show concentrations of triclosan reaching 183.8 ng/g d.w in North Sea mackerel, and 36.4 ng/g d.w of bisphenol A in canned mackerel from Portugal. Furthermore, there has been an increasing concentration of EDCs when samples were steamed until reaching 75.4 ng/g d.w of bisphenol A in gold. Regarding levels PHACS the highest value was 11.72 ng/g d.w sulfamethoxazole of mussels from Holland. Although the levels detected in some cases are considerable not exceed the maximum levels permitted by the EU. To EDCs measured levels would not present any risk to public health in accordance with the tolerable daily maximum values recommended by the World Health Organization (WHO)

Manager: Salvadó Martín, Victòria
Álvarez-Muñoz, Diana
Other contributions: Universitat de Girona. Facultat de Ciències
Author: Gil Arroyo, Carlos E.
Date: 2015 September
Abstract: In recent years it has detected the presence of pharmaceuticals and endocrine disruptors in aquatic environments. These compounds may accumulate in marine organisms such as fish and shellfish if longZterm exposure and consumption of these organisms occurs could cause a risk to human health. With the main objective to assess this risk arises the European project "Priority environmental contaminants in seafood: safety assessment, impact and public perception" (ECsafeSEAFOOD) within which development has this work. It has analyzed samples of fish and shellfish for human consumption, mainly from different European regions, but have also included some samples of imported organisms. The compounds under study were diruptores endocrine compounds (EDCs) particularly triclosan, methylparaben, bisphenol A and TBEP and pharmacologically active compounds (PHACS) such as diazepam, sotalol, azithromycin, carbamazepine, diclofenac, citalopram, venlafaxine and sulfamethoxazole. Two samplings were conducted at different times of year and also the second one of the samples were steamed. The analysis of samples was performed using two analytical methods multiresidue. The protocol followed for EDCs is based on the use of QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe [fast, easy, economical, efficient, robust and secure]). for extraction and purification sample, while for PHACS pressurized extraction with solvents (PLE) followed by a purification step with gel chromatography (GPC) was use. In both cases the detection and quantification of samples end was performed by chromatography coupled to mass spectrometry (UHPLCZMS) liquid. The results show concentrations of triclosan reaching 183.8 ng/g d.w in North Sea mackerel, and 36.4 ng/g d.w of bisphenol A in canned mackerel from Portugal. Furthermore, there has been an increasing concentration of EDCs when samples were steamed until reaching 75.4 ng/g d.w of bisphenol A in gold. Regarding levels PHACS the highest value was 11.72 ng/g d.w sulfamethoxazole of mussels from Holland. Although the levels detected in some cases are considerable not exceed the maximum levels permitted by the EU. To EDCs measured levels would not present any risk to public health in accordance with the tolerable daily maximum values recommended by the World Health Organization (WHO)
Format: application/pdf
Document access: http://hdl.handle.net/10256/11859
Language: spa
Collection: Ciències Ambientals (TFG)
Rights: Attribution-NonCommercial-NoDerivs 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Subject: Disruptors endocrins
Peixos -- Efecte dels medicaments
Peixos -- Efecte dels productes químics
Peixos -- Efecte de la contaminació de l’aigua
Marisc -- Efecte dels medicaments
Marisc -- Efecte dels productes químics
Marisc -- Efecte de la contaminació de l’aigua
Endocrine disrupting chemicals
Fishes -- Effect of drugs on
Fishes -- Effect of chemicals on
Fishes -- Effect of water pollution on
Seafood -- Effect of drugs on
Seafood -- Effect of chemicals on
Seafood -- Effect of water pollution on
Title: Análisis de fármacos y disruptores endocrinos en peces y moluscos destinados al consumo humano
Type: info:eu-repo/semantics/bachelorThesis
Repository: DUGiDocs

Subjects

Authors