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Speciation of arsenic in saliva samples from a population of West Bengal, India

Saliva, an easily accessible biofluid, is validated as biomarker of arsenic (As) exposure in several villages of West Bengal, India. Pentavalent arsenic [As(V)] was found to be the predominant species in saliva, with the amount of inorganic As [As(V) and trivalent form, As(III)] being more than half of the total As in the samples. Significant association was found between total daily ingestion of As and As(V) (r = 0.59; p = 0.000), As(III) (r = 0.60; p = 0.000), dimethylarsinous acid (DMAV) (r = 0.40; p = 0.000), and monomethylarsonous acid (MMAV) (r = 0.44; p = 0.000), implying that these species have mainly been derived from the methylation of the inorganic As in the water that study participants drank and the food they ate. Analysis of confounding effects of age, sex, smoking, body mass index and the prevalence of skin lesion suggests that women and controls with no skin lesion had a higher capacity to methylate the ingested As compared to the rest of the population. Thus, our study demonstrates that As species in saliva can be an useful tool to predict the individual susceptibility where higher As exposure and a lower methylation capacity are implicated in the development of As-induced health effects

We also acknowledge the support from the Spanish National Research Programme (CGL2010-22168-C03-03). S.B. and D.H. acknowledge Erasmus Mundus External Cooperation Window (EMECW Action II) Program EUR-INDIA

© Environmental Science and Technology, 2014, vol. 48, núm. 12, p. 6973-6980

American Chemical Society (ACS)

Author: Bhowmick, Subhamoy
Halder, Dipti
Nriagu, Jerome
Guha Mazumder, Debendra Nath
Roman-Ross, Gabriela
Chatterjee, Debashis
Iglesias Juncà, Mònica
Date: 2014
Abstract: Saliva, an easily accessible biofluid, is validated as biomarker of arsenic (As) exposure in several villages of West Bengal, India. Pentavalent arsenic [As(V)] was found to be the predominant species in saliva, with the amount of inorganic As [As(V) and trivalent form, As(III)] being more than half of the total As in the samples. Significant association was found between total daily ingestion of As and As(V) (r = 0.59; p = 0.000), As(III) (r = 0.60; p = 0.000), dimethylarsinous acid (DMAV) (r = 0.40; p = 0.000), and monomethylarsonous acid (MMAV) (r = 0.44; p = 0.000), implying that these species have mainly been derived from the methylation of the inorganic As in the water that study participants drank and the food they ate. Analysis of confounding effects of age, sex, smoking, body mass index and the prevalence of skin lesion suggests that women and controls with no skin lesion had a higher capacity to methylate the ingested As compared to the rest of the population. Thus, our study demonstrates that As species in saliva can be an useful tool to predict the individual susceptibility where higher As exposure and a lower methylation capacity are implicated in the development of As-induced health effects
We also acknowledge the support from the Spanish National Research Programme (CGL2010-22168-C03-03). S.B. and D.H. acknowledge Erasmus Mundus External Cooperation Window (EMECW Action II) Program EUR-INDIA
Format: application/pdf
ISSN: 0013-936X (versió paper)
1520-5851 (versió electrònica)
Document access: http://hdl.handle.net/10256/11949
Language: eng
Publisher: American Chemical Society (ACS)
Collection: MICINN/PN 2011-2013/CGL2010-22168-C03-0
Reproducció digital del document publicat a: http://dx.doi.org/10.1021/es4056142
Articles publicats (D-Q)
Is part of: © Environmental Science and Technology, 2014, vol. 48, núm. 12, p. 6973-6980
Rights: Tots els drets reservats
Subject: Marcadors bioquímics
Biochemical markers
Aigua potable -- India
Drinking water -- India
Arsènic
Arsenic
Title: Speciation of arsenic in saliva samples from a population of West Bengal, India
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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