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O2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper m-h1:h1 -Peroxido Complex

Unusual reactivity: A novel unsymmetric dicopper complex gives rise to the unsymmetric species 1-O2 having a μ-η1:η1-O2 binding mode and reactivity patterns not previously observed for symmetric analogues. It is unreactive in oxygen atom transfer reactions, but it can selectively bind phenolate and mediate its ortho hydroxylation, thereby demonstrating a conceptually different tyrosinase model with exquisite selectivity

El mateix article està publicat en alemany a l’edició alemanya d’ ’Angewandte Chemie’ (ISSN 0044-8249, EISSN 1521-3757), 2010, vol. 122, núm. 13, p.2456–2459. DOI http://dx.doi.org/10.1002/ange.200906749

This work was supported financially by MCYT of Spain (projects CTQ2006-05367/BQU and CTQ2009-08464/BQU to M.C.), by the U.S. NIH (grant GM38767 to L.Q.), and by the Italian MIUR (Prin project to L.L.). I.G.B and A.C. thank MICINN for PhD grants. M.T.- S. thanks the CSIC for the JAE-DOC contract. We thank STR-UdG for technical support. M.C. also thanks the Generalitat Catalunya for an ICREA-Academia award and for project 2009 SGR-637

© Angewandte Chemie International Edition, 2010, vol. 49. núm. 13, p. 2406-2409

Wiley-VCH Verlag

Author: Garcia Bosch, Isaac
Company Casadevall, Anna
Frisch, Jonathan R.
Torrent Sucarrat, Miquel
Cardellach, Mar
Gamba, Ilaria
Güell Serra, Mireia
Casella, Luigi
Que, Lawrence
Ribas Salamaña, Xavi
Luis Luis, Josep Maria
Costas Salgueiro, Miquel
Date: 2010
Abstract: Unusual reactivity: A novel unsymmetric dicopper complex gives rise to the unsymmetric species 1-O2 having a μ-η1:η1-O2 binding mode and reactivity patterns not previously observed for symmetric analogues. It is unreactive in oxygen atom transfer reactions, but it can selectively bind phenolate and mediate its ortho hydroxylation, thereby demonstrating a conceptually different tyrosinase model with exquisite selectivity
El mateix article està publicat en alemany a l’edició alemanya d’ ’Angewandte Chemie’ (ISSN 0044-8249, EISSN 1521-3757), 2010, vol. 122, núm. 13, p.2456–2459. DOI http://dx.doi.org/10.1002/ange.200906749
This work was supported financially by MCYT of Spain (projects CTQ2006-05367/BQU and CTQ2009-08464/BQU to M.C.), by the U.S. NIH (grant GM38767 to L.Q.), and by the Italian MIUR (Prin project to L.L.). I.G.B and A.C. thank MICINN for PhD grants. M.T.- S. thanks the CSIC for the JAE-DOC contract. We thank STR-UdG for technical support. M.C. also thanks the Generalitat Catalunya for an ICREA-Academia award and for project 2009 SGR-637
Format: application/pdf
ISSN: 1433-7851 (versió paper)
1521-3773 (versió electrònica)
Document access: http://hdl.handle.net/10256/12255
Language: eng
Publisher: Wiley-VCH Verlag
Collection: MICINN/PN 2010-2012/ CTQ2009-08464
MEC/PN 2006-2009/ CTQ2006- 05367/BQU
AGAUR/2009-2014/2009 SGR-637
Reproducció digital del document publicat a: http://dx.doi.org/10.1002/anie.200906749
Articles publicats (D-Q)
Is part of: © Angewandte Chemie International Edition, 2010, vol. 49. núm. 13, p. 2406-2409
Rights: Tots els drets reservats
Subject: Reactivitat (Química)
Reactivity (Chemistry)
Reaccions químiques
Chemical reactions
Title: O2 Activation and Selective Phenolate ortho Hydroxylation by an Unsymmetric Dicopper m-h1:h1 -Peroxido Complex
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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