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Enantiomeric-selective determination of pyrethroids: application to human samples

Recently, some works point out the bioaccumulation of pyrethroids in humans. Given the chiral properties of pyrethroids, our goal in this work was to develop a gas chromatography (GC)-MS-MS methodology for the enantioselective analysis of six common pyrethroids. For the first time, we separate the enantiomers of bifenthrin, cyhalothrin, cyfluthrin, cypermethrin, permethrin and tetramethrin in a single analysis of less than 75 min and with resolutions greater than 0.58 in all cases. The developed method proved to be reproducible (with relative standard deviations under 3 %) and sensitive (with instrumental limits of detection from 4 to 49 fg) enough to evaluate the enantiomeric distribution of these pyrethroids. The developed methodology was applied to commercial insecticides and human breast milk samples. Some potential selective bioaccumulation for cyhalothrin, cyperpermethrin and tetramethrin was described in humans

This work has been supported by the Spanish Ministry of Economy and Competitiveness through the project Consolider-Ingenio (2010 CSD2009-00065). This work has also been partly funded by the Generalitat de Catalunya (Consolidated Research Group Water and Soil Quality Unit 2009-SGR-965)

© Analytical and Bioanalytical Chemistry, 2014, vol. 407, núm. 3, p. 779-786

Elsevier

Author: Corcellas, Cayo
Eljarrat, Ethel
Barceló i Cullerés, Damià
Date: 2014 June 11
Abstract: Recently, some works point out the bioaccumulation of pyrethroids in humans. Given the chiral properties of pyrethroids, our goal in this work was to develop a gas chromatography (GC)-MS-MS methodology for the enantioselective analysis of six common pyrethroids. For the first time, we separate the enantiomers of bifenthrin, cyhalothrin, cyfluthrin, cypermethrin, permethrin and tetramethrin in a single analysis of less than 75 min and with resolutions greater than 0.58 in all cases. The developed method proved to be reproducible (with relative standard deviations under 3 %) and sensitive (with instrumental limits of detection from 4 to 49 fg) enough to evaluate the enantiomeric distribution of these pyrethroids. The developed methodology was applied to commercial insecticides and human breast milk samples. Some potential selective bioaccumulation for cyhalothrin, cyperpermethrin and tetramethrin was described in humans
This work has been supported by the Spanish Ministry of Economy and Competitiveness through the project Consolider-Ingenio (2010 CSD2009-00065). This work has also been partly funded by the Generalitat de Catalunya (Consolidated Research Group Water and Soil Quality Unit 2009-SGR-965)
Format: application/pdf
ISSN: 1618-2642 (versió paper)
1618-2650 (versió electrònica)
Document access: http://hdl.handle.net/10256/12581
Language: eng
Publisher: Elsevier
Collection: MICINN/PN 2009-2014/CSD2009-00065
Reproducció digital del document publicat a: http://dx.doi.org/10.1007/s00216-014-7905-6
Articles publicats (ICRA)
Is part of: © Analytical and Bioanalytical Chemistry, 2014, vol. 407, núm. 3, p. 779-786
Rights: Tots els drets reservats
Subject: Persones -- Efecte dels insecticides
Persons -- Effect of insecticides on
Insecticides -- Toxicologia
Insecticides -- Toxicology
Cromatografia de gasos
Gas chromatography
Title: Enantiomeric-selective determination of pyrethroids: application to human samples
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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