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Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe

The ocurrence and levels of PhACs, Endocrine Disrupting and related Compounds (EDCs) in seafood from potential contaminated areas in Europe has been studied. Macroalgae (S. accharina latissima and Laminaria digitata), bivalves (Mytilus galloprovincialis, Mytilus spp., Chamalea gallina and Crassostrea gigas) and fish (Liza aurata and Platichthys flesus) from Portugal, Spain, Italy, Netherlands, and Norway were analysed following 4 different analytical protocols depending on the organism and target group of contaminants. The results revealed the presence of 4 pharmaceutical compounds in macroalgae samples, 16 in bivalves and 10 in fish. To the best of our knowledge, this is the first time that PhACs have been detected in marine fish and in macroalgae. Besides, this is also the first time that dimetridazole, hydrochlorothiazide and tamsulosin have been detected in biota samples. The highest levels of PhACs corresponded to the psychiatric drug velanfaxine (up to 36.1 ng/g dry weight (dw)) and the antibiotic azithromycin (up to 13.3 ng/g dw) in bivalves from the Po delta (Italy). EDCs were not detected in macroalgae samples, however, the analysis revealed the presence of 10 EDCs in bivalves and 8 in fish. The highest levels corresponded to the organophosphorus flame retardant tris(2-butoxyethyl)phosphate (TBEP) reaching up to 98.4 ng/g dw in mullet fish from the Tagus estuary. Bivalves, in particular mussels, have shown to be good bioindicator organisms for PhACs and fish for EDCs. Taking into consideration the concentrations and frequencies of detection of PhACs and EDCs in the seafood samples analysed, a list of candidates’ compounds for priorization in future studies has been proposed

The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the EC safe SEAFOOD project (Grant agreement no.311820). The scientific facilities of ICRA have been cofinanced by the Spanish Ministry of Economy and Competitiveness (MINECO) and by the European Regional Development Fund (ERDF) in the frame of theCatalonia ERDF Operative programm 2007–2013. This work was partly supported by the Generalitat de Catalunya (Consolidated Research Group: Catalan Institute for water Research 2014 SGR 291)

© Environmental Research, 2015, vol. 143, p. 56-64

Elsevier

Author: Álvarez Muñoz, Diana
Rodríguez Mozaz, Sara
Maulvaul, A.L.
Tediosi, A.
Fernández Tejedor, M.
Heuvel, F. van den
Kotterman, M.
Marques, Antonio
Barceló i Cullerés, Damià
Abstract: The ocurrence and levels of PhACs, Endocrine Disrupting and related Compounds (EDCs) in seafood from potential contaminated areas in Europe has been studied. Macroalgae (S. accharina latissima and Laminaria digitata), bivalves (Mytilus galloprovincialis, Mytilus spp., Chamalea gallina and Crassostrea gigas) and fish (Liza aurata and Platichthys flesus) from Portugal, Spain, Italy, Netherlands, and Norway were analysed following 4 different analytical protocols depending on the organism and target group of contaminants. The results revealed the presence of 4 pharmaceutical compounds in macroalgae samples, 16 in bivalves and 10 in fish. To the best of our knowledge, this is the first time that PhACs have been detected in marine fish and in macroalgae. Besides, this is also the first time that dimetridazole, hydrochlorothiazide and tamsulosin have been detected in biota samples. The highest levels of PhACs corresponded to the psychiatric drug velanfaxine (up to 36.1 ng/g dry weight (dw)) and the antibiotic azithromycin (up to 13.3 ng/g dw) in bivalves from the Po delta (Italy). EDCs were not detected in macroalgae samples, however, the analysis revealed the presence of 10 EDCs in bivalves and 8 in fish. The highest levels corresponded to the organophosphorus flame retardant tris(2-butoxyethyl)phosphate (TBEP) reaching up to 98.4 ng/g dw in mullet fish from the Tagus estuary. Bivalves, in particular mussels, have shown to be good bioindicator organisms for PhACs and fish for EDCs. Taking into consideration the concentrations and frequencies of detection of PhACs and EDCs in the seafood samples analysed, a list of candidates’ compounds for priorization in future studies has been proposed
The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under the EC safe SEAFOOD project (Grant agreement no.311820). The scientific facilities of ICRA have been cofinanced by the Spanish Ministry of Economy and Competitiveness (MINECO) and by the European Regional Development Fund (ERDF) in the frame of theCatalonia ERDF Operative programm 2007–2013. This work was partly supported by the Generalitat de Catalunya (Consolidated Research Group: Catalan Institute for water Research 2014 SGR 291)
Format: application/pdf
ISSN: 0013-9351 (versió paper)
1096-0953 (versió electrònica)
Document access: http://hdl.handle.net/10256/12615
Language: eng
Publisher: Elsevier
Collection: Reproducció digital del document publicat a: http://dx.doi.org/10.1016/j.envres.2015.09.018
Articles publicats (ICRA)
info:eu-repo/grantAgreement/EC/FP7/311820
Is part of: © Environmental Research, 2015, vol. 143, p. 56-64
Rights: Tots els drets reservats
Subject: Disruptors endocrins
Endocrine disrupting chemicals
Mar -- Contaminació
Marine pollution
Title: Occurrence of pharmaceuticals and endocrine disrupting compounds in macroalgaes, bivalves, and fish from coastal areas in Europe
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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