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A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water

A sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammatory drugs, five iodinated contrast media, β-blockers and some of their metabolites and transformation products in water samples. Few other methods are capable of determining such a broad range of contrast media together with other analytes. We studied the parameters affecting the extraction of the target analytes, including sorbent selection and extraction conditions, their chromatographic separation (mobile phase composition and column) and detection conditions using two ionisation sources: electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI). In order to correct matrix effects, a total of 20 surrogate/internal standards were used. ESI was found to have better sensitivity than APCI. Recoveries ranging from 79 to 134 % for tap water and 66 to 144 % for surface water were obtained. Intra-day precision, calculated as relative standard deviation, was below 34 % for tap water and below 21 % for surface water, groundwater and effluent wastewater. Method quantification limits (MQL) were in the low ng L−1 range, except for the contrast agents iomeprol, amidotrizoic acid and iohexol (22, 25.5 and 17.9 ng L−1, respectively). Finally, the method was applied to the analysis of 56 real water samples as part of the validation procedure. All of the compounds were detected in at least some of the water samples analysed

This study was financed by the SpanishMinistry of Science and Innovation through projects CTM2011-28765-C02-02 and CGL2013-48802-C3-2-R, and an FPI grant (Ref. BES-2009-024892) awarded to C. Valls-Cantenys

© Analytical and Bioanalytical Chemistry, 2016, vol. 408, núm. 22, p. 6189-6200

Springer Verlag

Author: Valls Cantenys, Carme
Scheurer, Marco
Iglesias Juncà, Mònica
Sacher, Frank
Brauch, Heinz Jürgen
Salvadó Martín, Victòria
Date: 2016 September 1
Abstract: A sensitive, multi-residue method using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine a representative group of 35 analytes, including corrosion inhibitors, pesticides and pharmaceuticals such as analgesic and anti-inflammatory drugs, five iodinated contrast media, β-blockers and some of their metabolites and transformation products in water samples. Few other methods are capable of determining such a broad range of contrast media together with other analytes. We studied the parameters affecting the extraction of the target analytes, including sorbent selection and extraction conditions, their chromatographic separation (mobile phase composition and column) and detection conditions using two ionisation sources: electrospray ionisation (ESI) and atmospheric pressure chemical ionisation (APCI). In order to correct matrix effects, a total of 20 surrogate/internal standards were used. ESI was found to have better sensitivity than APCI. Recoveries ranging from 79 to 134 % for tap water and 66 to 144 % for surface water were obtained. Intra-day precision, calculated as relative standard deviation, was below 34 % for tap water and below 21 % for surface water, groundwater and effluent wastewater. Method quantification limits (MQL) were in the low ng L−1 range, except for the contrast agents iomeprol, amidotrizoic acid and iohexol (22, 25.5 and 17.9 ng L−1, respectively). Finally, the method was applied to the analysis of 56 real water samples as part of the validation procedure. All of the compounds were detected in at least some of the water samples analysed
This study was financed by the SpanishMinistry of Science and Innovation through projects CTM2011-28765-C02-02 and CGL2013-48802-C3-2-R, and an FPI grant (Ref. BES-2009-024892) awarded to C. Valls-Cantenys
Format: application/pdf
ISSN: 1618-2642 (versió paper)
1618-2650 (versió electrònica)
Document access: http://hdl.handle.net/10256/13130
Language: eng
Publisher: Springer Verlag
Collection: MICINN/PN 2012-2012/CTM2011-28765-C02-02
MINECO/PE 2013-2016/CGL2013-48802-C3-2-R
Reproducció digital del document publicat a: http://dx.doi.org/10.1007/s00216-016-9731-5
Articles publicats (D-Q)
Is part of: © Analytical and Bioanalytical Chemistry, 2016, vol. 408, núm. 22, p. 6189-6200
Rights: Tots els drets reservats
Subject: Cromatografia de líquids
Liquid chromatography
Contaminants emergents en l’aigua
Emerging contaminants in water
Aigua -- Contaminació
Water -- Pollution
Title: A sensitive multi-residue method for the determination of 35 micropollutants including pharmaceuticals, iodinated contrast media and pesticides in water
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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