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Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases

The photophysics and photochemistry of DNA is of great importance due to the potential damage of the genetic code by UV light. Quantum mechanical studies have played a key role in interpretating the results of modern time-resolved pump-probe spectroscopy, and in elucidating the main photoactivated reactive paths. This review provides a concise, complete picture of the computational studies carried out, approximately, in the past decade. We start with an overview of the photophysics of the nucleobases in the gas phase and in solution. We discuss the proposed mechanisms for ultrafast decay to the ground state, that involve conical intersections, consider the role of triplet states, and analyze how the solvent modulates the photophysics. Then we move to larger systems, from dinucleotides to single- and double-stranded oligonucleotides. We focus on the possible role of charge transfer and delocalized or excitonic states in the photophysics of these systems and discuss the main photochemical paths. We finish with an outlook on the current challenges in the field and future directions of research

R.I. and F.S. acknowledge support from Italian MIUR (PRIN 2010-2011 Prot. 2010ERFXKL), RI from LeggeRegionale5 2007 Campania and Progetto Bilaterale PICS CNR/CNRS, and L.B. acknowledges support by Grant 2014SGR1202 from the Agència de Gestiód’Ajuts Universitaris i de Recerca (AGAUR) from Catalonia (Spain) and Grant CTQ2015-69363-P from the Ministerio de Economıá y Competividad (Spain)

© Chemical Reviews, 2016, vol. 116, núm. 6, p. 3540-3593

American Chemical Society (ACS)

Author: Improta, Roberto
Santoro, Fabrizio
Blancafort San José, Lluís
Date: 2016 March 23
Abstract: The photophysics and photochemistry of DNA is of great importance due to the potential damage of the genetic code by UV light. Quantum mechanical studies have played a key role in interpretating the results of modern time-resolved pump-probe spectroscopy, and in elucidating the main photoactivated reactive paths. This review provides a concise, complete picture of the computational studies carried out, approximately, in the past decade. We start with an overview of the photophysics of the nucleobases in the gas phase and in solution. We discuss the proposed mechanisms for ultrafast decay to the ground state, that involve conical intersections, consider the role of triplet states, and analyze how the solvent modulates the photophysics. Then we move to larger systems, from dinucleotides to single- and double-stranded oligonucleotides. We focus on the possible role of charge transfer and delocalized or excitonic states in the photophysics of these systems and discuss the main photochemical paths. We finish with an outlook on the current challenges in the field and future directions of research
R.I. and F.S. acknowledge support from Italian MIUR (PRIN 2010-2011 Prot. 2010ERFXKL), RI from LeggeRegionale5 2007 Campania and Progetto Bilaterale PICS CNR/CNRS, and L.B. acknowledges support by Grant 2014SGR1202 from the Agència de Gestiód’Ajuts Universitaris i de Recerca (AGAUR) from Catalonia (Spain) and Grant CTQ2015-69363-P from the Ministerio de Economıá y Competividad (Spain)
Format: application/pdf
ISSN: 0009-2665 (versió paper)
1520-6890 (versió electrònica)
Document access: http://hdl.handle.net/10256/13170
Language: eng
Publisher: American Chemical Society (ACS)
Collection: MINECO/PE 2015-2017/CTQ2015-69363-P
AGAUR/2014-2017/2014SGR1202
Reproducció digital del document publicat a: http://dx.doi.org/10.1021/acs.chemrev.5b00444
Articles publicats (D-Q)
Is part of: © Chemical Reviews, 2016, vol. 116, núm. 6, p. 3540-3593
Rights: Tots els drets reservats
Subject: Quàntums, Teoria dels
Quantum theory
Fotoquímica
Photochemistry
Title: Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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