Item
Ministerio de Economía y Competitividad (Espanya)
Generalitat de Catalunya. Agència de Gestió d’Ajuts Universitaris i de Recerca |
|
Improta, Roberto
Santoro, Fabrizio Blancafort San José, Lluís |
|
2016 March 23 | |
The photophysics and photochemistry of DNA is of great importance due to the potential damage of the genetic code by UV light. Quantum mechanical studies have played a key role in interpretating the results of modern time-resolved pump-probe spectroscopy, and in elucidating the main photoactivated reactive paths. This review provides a concise, complete picture of the computational studies carried out, approximately, in the past decade. We start with an overview of the photophysics of the nucleobases in the gas phase and in solution. We discuss the proposed mechanisms for ultrafast decay to the ground state, that involve conical intersections, consider the role of triplet states, and analyze how the solvent modulates the photophysics. Then we move to larger systems, from dinucleotides to single- and double-stranded oligonucleotides. We focus on the possible role of charge transfer and delocalized or excitonic states in the photophysics of these systems and discuss the main photochemical paths. We finish with an outlook on the current challenges in the field and future directions of research R.I. and F.S. acknowledge support from Italian MIUR (PRIN 2010-2011 Prot. 2010ERFXKL), RI from LeggeRegionale5 2007 Campania and Progetto Bilaterale PICS CNR/CNRS, and L.B. acknowledges support by Grant 2014SGR1202 from the Agència de Gestiód’Ajuts Universitaris i de Recerca (AGAUR) from Catalonia (Spain) and Grant CTQ2015-69363-P from the Ministerio de Economıá y Competividad (Spain) |
|
application/pdf | |
http://hdl.handle.net/10256/13170 | |
eng | |
American Chemical Society (ACS) | |
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.chemrev.5b00444 info:eu-repo/semantics/altIdentifier/issn/0009-2665 info:eu-repo/semantics/altIdentifier/eissn/1520-6890 info:eu-repo/grantAgreement/MINECO//CTQ2015-69363-P/ES/OMPUTACION DEL ESTADO EXCITADO: DE ESPECTROS MOLECULARES A SISTEMAS MULTICROMOFORICOS/ AGAUR/2014-2017/2014SGR1202 |
|
Tots els drets reservats | |
Quàntums, Teoria dels
Quantum theory Fotoquímica Photochemistry |
|
Quantum Mechanical Studies on the Photophysics and the Photochemistry of Nucleic Acids and Nucleobases | |
info:eu-repo/semantics/article | |
DUGiDocs |