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Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond

The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr1 and a d-Tyr7 led to the most stable sequences

This work was financed by Grant AGL2012-39880-C02-02

American Chemical Society (ACS)

Director: Ministerio de Ciencia e Innovación (Espanya)
Autor: Rosés Subirós, Cristina
Camó Marín, Cristina
Vogels, Kristy
Planas i Grabuleda, Marta
Feliu Soley, Lídia
Data: 19 agost 2016
Resum: The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr1 and a d-Tyr7 led to the most stable sequences
This work was financed by Grant AGL2012-39880-C02-02
Format: application/pdf
Accés al document: http://hdl.handle.net/10256/13671
Llenguatge: eng
Editor: American Chemical Society (ACS)
Col·lecció: info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.orglett.6b02281
info:eu-repo/semantics/altIdentifier/issn/1523-7060
info:eu-repo/semantics/altIdentifier/eissn/1523-7052
info:eu-repo/grantAgreement/MINECO//AGL2012-39880-C02-02/ES/NUEVAS ESTRATEGIAS DE CONTROL DEL FUEGO BACTERIANO. PEPTIDOS SINTETICOS ESTIMULADORES DE DEFENSA EN EL HUESPED/
Drets: Tots els drets reservats
Matèria: Pèptids -- Síntesi
Peptides -- Synthesis
Depsipèptid
Depsipeptide
Títol: Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

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