DUGi: Item | DUGiDocs - Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond

Item

Manager:	Ministerio de Ciencia e Innovación (Espanya)
Author:	Rosés Subirós, Cristina Camó Marín, Cristina Vogels, Kristy Planas i Grabuleda, Marta Feliu Soley, Lídia
Abstract:	The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr1 and a d-Tyr7 led to the most stable sequences This work was financed by Grant AGL2012-39880-C02-02
Format:	application/pdf
Document access:	http://hdl.handle.net/10256/13671
Language:	eng
Publisher:	American Chemical Society (ACS)
Collection:	info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.orglett.6b02281 info:eu-repo/semantics/altIdentifier/issn/1523-7060 info:eu-repo/semantics/altIdentifier/eissn/1523-7052 info:eu-repo/grantAgreement/MINECO//AGL2012-39880-C02-02/ES/NUEVAS ESTRATEGIAS DE CONTROL DEL FUEGO BACTERIANO. PEPTIDOS SINTETICOS ESTIMULADORES DE DEFENSA EN EL HUESPED/
Rights:	Tots els drets reservats
Subject:	Pèptids -- Síntesi Peptides -- Synthesis Depsipèptid Depsipeptide
Title:	Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond
Type:	info:eu-repo/semantics/article
Repository:	DUGiDocs