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Determination of pharmaceutical compounds in sewage sludge using a standard addition method approach

An analytical method for the simultaneous determination of eight pharmaceutical compounds in biosolids from urban wastewater treatment plants (WWTPs) was developed and validated. The compounds evaluated were non-steroidal anti-inflammatory drugs (naproxen, diclofenac, and ibuprofen), lipid regulators (clofibric acid), and antibiotics (sulfathiazole, sulfapyridine, sulfamethazine, and sulfamethoxazole). Ultrasound assisted extraction with a water–methanol solvent mixture (1:1, v:v) was performed and the compounds were then determined by liquid chromatography coupled with tandem mass spectrometry. The design of the method was based on the application of the standard addition calibration methodology to reduce matrix interferences. Validation procedures were conducted with rabbit excrements as blank samples. Recoveries of the target analytes ranged from 76 to 131% in spiked samples at 50, 200 or 1000 ng g−1 dry weight (dw). The relative standard deviations were in the range of 5–15% and the method detection limits ranged from 2 to 12 ng g−1dw. The method was applied to monitor pharmaceutical concentrations in biosolids from different WWTPs over an eight-month period (May to December 2011). Diclofenac, sulfapyridine and ibuprofen were detected in most of the samples whereas sulfamethazine and ibuprofen were the pharmaceuticals found in the highest concentrations (>200 ng g−1 dw on average)

The financial support of the Ministerio de Ciencia e Inovación through projects CTM2008-0647-C02-02/TECNO, CTM2011-28765-C02-02 and CGL2010-22168-C03-03 is gratefully acknowledged

© International Journal of Environmental Analytical Chemistry, 2014, vol. 94, núm. 12, p. 1199-1209

Taylor and Francis

Author: Garcia-Rodríguez, Aida
Sagristà Puig, Ester
Matamoros, Víctor
Fontàs Rigau, Clàudia
Hidalgo Muñoz, Manuela
Salvadó Martín, Victòria
Date: 2014 August 12
Abstract: An analytical method for the simultaneous determination of eight pharmaceutical compounds in biosolids from urban wastewater treatment plants (WWTPs) was developed and validated. The compounds evaluated were non-steroidal anti-inflammatory drugs (naproxen, diclofenac, and ibuprofen), lipid regulators (clofibric acid), and antibiotics (sulfathiazole, sulfapyridine, sulfamethazine, and sulfamethoxazole). Ultrasound assisted extraction with a water–methanol solvent mixture (1:1, v:v) was performed and the compounds were then determined by liquid chromatography coupled with tandem mass spectrometry. The design of the method was based on the application of the standard addition calibration methodology to reduce matrix interferences. Validation procedures were conducted with rabbit excrements as blank samples. Recoveries of the target analytes ranged from 76 to 131% in spiked samples at 50, 200 or 1000 ng g−1 dry weight (dw). The relative standard deviations were in the range of 5–15% and the method detection limits ranged from 2 to 12 ng g−1dw. The method was applied to monitor pharmaceutical concentrations in biosolids from different WWTPs over an eight-month period (May to December 2011). Diclofenac, sulfapyridine and ibuprofen were detected in most of the samples whereas sulfamethazine and ibuprofen were the pharmaceuticals found in the highest concentrations (>200 ng g−1 dw on average)
The financial support of the Ministerio de Ciencia e Inovación through projects CTM2008-0647-C02-02/TECNO, CTM2011-28765-C02-02 and CGL2010-22168-C03-03 is gratefully acknowledged
Format: application/pdf
ISSN: 0306-7319 (versió paper)
1029-0397 (versió electrònica)
Document access: http://hdl.handle.net/10256/13698
Language: eng
Publisher: Taylor and Francis
Collection: MICINN/PN 2012-2012/CTM2011-28765-C02-02
MICINN/PN 2011-2013/CGL2010-22168-C03-0
Reproducció digital del document publicat a: http://dx.doi.org/10.1080/03067319.2014.921292
Articles publicats (D-Q)
Is part of: © International Journal of Environmental Analytical Chemistry, 2014, vol. 94, núm. 12, p. 1199-1209
Rights: Tots els drets reservats
Subject: Contaminants emergents en l’aigua
Emerging contaminants in water
Aigües residuals -- Plantes de tractament
Sewage disposal plants
Title: Determination of pharmaceutical compounds in sewage sludge using a standard addition method approach
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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