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Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma

Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses. Results We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy. Conclusions The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastoma

PLoS One, 2016, vol. 11, núm. 7, p. e0158887

Public Library of Science (PLoS)

Author: Puig Alcántara, Josep
Sánchez González, Javier
Blasco Solà, Gerard
Daunis i Estadella, Josep
Federau, Christian
Alberich Bayarri, Ángel
Biarnes, Carles
Nael, Kambiz
Essig, Marco
Jain, Rajan
Wintermark, Max
Pedraza Gutiérrez, Salvador
Date: 2016 July 7
Abstract: Intravoxel incoherent motion (IVIM) is an MRI technique with potential applications in measuring brain tumor perfusion, but its clinical impact remains to be determined. We assessed the usefulness of IVIM-metrics in predicting survival in newly diagnosed glioblastoma. Methods Fifteen patients with glioblastoma underwent MRI including spin-echo echo-planar DWI using 13 b-values ranging from 0 to 1000 s/mm2. Parametric maps for diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were generated for contrast-enhancing regions (CER) and non-enhancing regions (NCER). Regions of interest were manually drawn in regions of maximum f and on the corresponding dynamic susceptibility contrast images. Prognostic factors were evaluated by Kaplan-Meier survival and Cox proportional hazards analyses. Results We found that fCER and D*CER correlated with rCBFCER. The best cutoffs for 6-month survival were fCER>9.86% and D*CER>21.712 x10−3mm2/s (100% sensitivity, 71.4% specificity, 100% and 80% positive predictive values, and 80% and 100% negative predictive values; AUC:0.893 and 0.857, respectively). Treatment yielded the highest hazard ratio (5.484; 95% CI: 1.162–25.88; AUC: 0.723; P = 0.031); fCER combined with treatment predicted survival with 100% accuracy. Conclusions The IVIM-metrics fCER and D*CER are promising biomarkers of 6-month survival in newly diagnosed glioblastoma
Format: application/pdf
Citation: https://doi.org/10.1371/journal.pone.0158887
ISSN: 1932-6203
Document access: http://hdl.handle.net/10256/14046
Language: eng
Publisher: Public Library of Science (PLoS)
Collection: Reproducció digital del document publicat a: https://doi.org/10.1371/journal.pone.0158887
Articles publicats (D-IMA)
Is part of: PLoS One, 2016, vol. 11, núm. 7, p. e0158887
Rights: Attribution 4.0 Spain
Rights URI: http://creativecommons.org/licenses/by4.0/es/
Subject: Ressonància magnètica
Magnetic resonance
Cervell -- Tumors
Brain -- Tumors
Gliomes
Gliomas
Title: Intravoxel Incoherent Motion Metrics as Potential Biomarkers for Survival in Glioblastoma
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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