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Model Csp2-Csp3 Hurtley Coupling Catalysis that Operates through a Well-Defined CuI/CuIII Mechanism

Hurtley-type coupling reactions, which were first discovered more than 80 years ago, involve the copper-catalyzed a-arylation of activated methylene compounds by using aryl halide substrates.[1–3] These reactions afford Csp2 Csp3 coupling products, usually as their a-aryl ketone derivatives. These compounds are important because they are found in a large number of natural products and they have also found wide application in pharmaceutical chemistry.[4] Importantly, there is not a clear understanding of the mechanistic details of copperbased Hurtley catalysis; therefore, unraveling the mechanistic pathways is of fundamental importance to facilitate the design of more-sustainable methodologie

We acknowledge financial support from the European Research Council for a Starting Grant Project to X.R. (ERC-2011-StG-277801), the MICINN of Spain (CTQ2009-08464/BQU to Dr. Costas and a PhD FPI grant to M.F.), the Consolider-Ingenio (CSD2010-00065), and the Catalan DIUE of the Generalitat de Catalunya (2009SGR637)

Wiley-VCH Verlag

Manager: Ministerio de Ciencia e Innovación (Espanya)
Author: Rovira Coll, Mireia
Font Molins, Marc
Ribas Salamaña, Xavi
Date: 2013 March
Abstract: Hurtley-type coupling reactions, which were first discovered more than 80 years ago, involve the copper-catalyzed a-arylation of activated methylene compounds by using aryl halide substrates.[1–3] These reactions afford Csp2 Csp3 coupling products, usually as their a-aryl ketone derivatives. These compounds are important because they are found in a large number of natural products and they have also found wide application in pharmaceutical chemistry.[4] Importantly, there is not a clear understanding of the mechanistic details of copperbased Hurtley catalysis; therefore, unraveling the mechanistic pathways is of fundamental importance to facilitate the design of more-sustainable methodologie
We acknowledge financial support from the European Research Council for a Starting Grant Project to X.R. (ERC-2011-StG-277801), the MICINN of Spain (CTQ2009-08464/BQU to Dr. Costas and a PhD FPI grant to M.F.), the Consolider-Ingenio (CSD2010-00065), and the Catalan DIUE of the Generalitat de Catalunya (2009SGR637)
Format: application/pdf
Document access: http://hdl.handle.net/10256/14121
Language: eng
Publisher: Wiley-VCH Verlag
Collection: info:eu-repo/semantics/altIdentifier/doi/10.1002/cctc.201200885
info:eu-repo/semantics/altIdentifier/issn/1867-3880
info:eu-repo/semantics/altIdentifier/eissn/1867-3899
MICINN/PN 2010-2012/ CTQ2009-08464
MICINN/PN 2010-2016/CSD2010-00065
info:eu-repo/grantAgreement/EC/FP7/277801/EU/Sustainable C-X and C-H Functionalization Catalyzed by Copper(III) Species/SUSCATCU3
Rights: Tots els drets reservats
Subject: Coure
Copper
Mecanismes de reacció (Química)
Reaction mechanisms (Chemistry)
Title: Model Csp2-Csp3 Hurtley Coupling Catalysis that Operates through a Well-Defined CuI/CuIII Mechanism
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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