Ítem


Obesity changes the human gut mycobiome

The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity

Scientific Reports, núm. 5, art. 14600

Nature Publishing Group

Autor: Rodríguez, M. Mar
Pérez, Daniel
Chaves, Felipe Javier
Esteve, Eduardo
Marin-Garcia, Pablo
Xifra Vilarroya, Gemma
Vendrell, Joan
Jové, Mariona
Pamplona, Reinald
Ricart, Wifredo
Portero Otin, Manuel
Chacón, Matilde R.
Fernández-Real Lemos, José Manuel
Data: 12 octubre 2015
Resum: The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity
Format: application/pdf
Cita: https://doi.org/10.1038/srep14600
ISSN: 2045-2322
Accés al document: http://hdl.handle.net/10256/14252
Llenguatge: eng
Editor: Nature Publishing Group
Col·lecció: Reproducció digital del document publicat a: https://doi.org/10.1038/srep14600
Articles publicats (IdIBGi)
És part de: Scientific Reports, núm. 5, art. 14600
Drets: Attribution 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by/3.0/es/
Matèria: Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
Títol: Obesity changes the human gut mycobiome
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

Matèries

Autors