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Unusual reactivity of rhodium carbenes with allenes: an efficient asymmetric synthesis of methylenetetrahydropyran scaffolds

A RhI/(S)-BINAP catalytic system is able to promote carbene alkyne metathesis and cascade this elemental step with an stereoselective reaction with allenes. An unusual carbene/allene reactivity is discovered that, through a formal addition of p-toluenesulfinic acid to a Rh-bound trimethylenemethane intermediate, affords 4-methylenetetrahydropyran compounds in good yields and excellent enantioselectivities

We are grateful for the financial support by the Spanish Ministry of Economy and Competitiveness (MINECO) (Project CTQ2014-54306-P) and the Generalitat de Catalunya (Project 2014-SGR-931, Xarxa de Referència en Química Teòrica i Computacional, ICREA Academia 2014 prize for M. S., and FI predoctoral grant to O.T.). The EU under the FEDER grant UNGI10-4E-801 has also funded this research

Chemical Communications, 2017, vol. 53, núm. 71, p. 9922 - 9925

Royal Society of Chemistry (RSC)

Author: Torres Antón, Òscar
Solà i Puig, Miquel
Roglans i Ribas, Anna
Pla i Quintana, Anna
Date: 2017 August 15
Abstract: A RhI/(S)-BINAP catalytic system is able to promote carbene alkyne metathesis and cascade this elemental step with an stereoselective reaction with allenes. An unusual carbene/allene reactivity is discovered that, through a formal addition of p-toluenesulfinic acid to a Rh-bound trimethylenemethane intermediate, affords 4-methylenetetrahydropyran compounds in good yields and excellent enantioselectivities
We are grateful for the financial support by the Spanish Ministry of Economy and Competitiveness (MINECO) (Project CTQ2014-54306-P) and the Generalitat de Catalunya (Project 2014-SGR-931, Xarxa de Referència en Química Teòrica i Computacional, ICREA Academia 2014 prize for M. S., and FI predoctoral grant to O.T.). The EU under the FEDER grant UNGI10-4E-801 has also funded this research
Format: application/pdf
Citation: https://doi.org/10.1039/C7CC04803C
ISSN: 1359-7345 (versió paper)
1364-548X (versió electrònica)
Document access: http://hdl.handle.net/10256/14365
Language: eng
Publisher: Royal Society of Chemistry (RSC)
Collection: MINECO/PE 2015-2017/CTQ2014-54306-P
Reproducció digital del document publicat a: https://doi.org/10.1039/C7CC04803C
Articles publicats (D-Q)
Is part of: Chemical Communications, 2017, vol. 53, núm. 71, p. 9922 - 9925
Rights: Attribution-NonCommercial 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by-nc/3.0/es/
Subject: Síntesi asimètrica
Asymmetric synthesis
Catalitzadors de rodi
Rhodium catalyst
Al·lens
Allenes
Title: Unusual reactivity of rhodium carbenes with allenes: an efficient asymmetric synthesis of methylenetetrahydropyran scaffolds
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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