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Microbial index in spondyloarthritis with and without inflammatory bowel disease

1. Abstract: A 60% of Spondyloarthritic patients have a subclinical low-degree chronic intestinal inflammation and a 7% of them will develop an Intestinal bowel disease. Currently, some studies demonstrate a dysbiosis on ankylosing spondylitis and a common immune disturbance background with intestinal bowel disease. F.Prausnitzii/ E.coli index has demonstrated significant differences between Crohn’s disease and Healthy controls. In this study, we want to know how this microbial index works as a marker on stool samples in patients with Ankylosing spondylitis with and without Intestinal bowel disease. 2. Objectives: To compare the microbial index (concentration of F.prausnitzii and E.coli) on stool sample in two groups of patients with ankylosing spondylitis; those with and without Crohn’s disease. 3. Population: a total of 60 Anti-TNF naïve patients will be included this study. 20 Chron’s disease patients (CDAI >220 low-mild moderate activity), 20 Spondylitis patients without IBD and 20 Spondylitis patients with IBD. 4. Design: Transversal descriptive study

Manager: Aldeguer i Manté, Xavier
Castells Cervelló, Xavier
Other contributions: Universitat de Girona. Facultat de Medicina
Author: Mijancos Aguirre, Carolina
Date: 2017 November
Abstract: 1. Abstract: A 60% of Spondyloarthritic patients have a subclinical low-degree chronic intestinal inflammation and a 7% of them will develop an Intestinal bowel disease. Currently, some studies demonstrate a dysbiosis on ankylosing spondylitis and a common immune disturbance background with intestinal bowel disease. F.Prausnitzii/ E.coli index has demonstrated significant differences between Crohn’s disease and Healthy controls. In this study, we want to know how this microbial index works as a marker on stool samples in patients with Ankylosing spondylitis with and without Intestinal bowel disease. 2. Objectives: To compare the microbial index (concentration of F.prausnitzii and E.coli) on stool sample in two groups of patients with ankylosing spondylitis; those with and without Crohn’s disease. 3. Population: a total of 60 Anti-TNF naïve patients will be included this study. 20 Chron’s disease patients (CDAI >220 low-mild moderate activity), 20 Spondylitis patients without IBD and 20 Spondylitis patients with IBD. 4. Design: Transversal descriptive study
Format: application/pdf
Document access: http://hdl.handle.net/10256/15674
Language: eng
Collection: Medicina (TFG)
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
Subject: Espondiloartropaties
Spondyloarthropathies
Espondiloartritis anquilosant
Ankylosing spondylitis
Intestins -- Inflamació
Inflammatory bowel diseases
Crohn, Malaltia de
Crohn’s disease
Microbiologia
Intestins -- Microbiologia
Intestines -- Microbiology
Title: Microbial index in spondyloarthritis with and without inflammatory bowel disease
Type: info:eu-repo/semantics/bachelorThesis
Repository: DUGiDocs

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