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Impact of an intervention on proinflammatory agents in asthmatic patients

Asthma is one of the most common chronic diseases among the chronic respiratory disorders, affecting around 334 million people worldwide. Exposure to different allergens and irritants has been shown to be a major source of asthma exacerbations and worsening of asthma symptoms. Therefore, apart from the basal treatment, asthmatics can benefit from other non-pharmacological measures in order to avoid these proinflammatory agents. The main purpose of this project is to evaluate the effectiveness of an intervention on proinflammatory agents for asthma exacerbations and asthma control. It will be a prospective, multicentre, pragmatical, controlled, randomized, open-label clinical trial. Patients enrolled in this study will be randomized in two groups. The intervention group (n=124) will have an intervention in order to avoid proinflammatory agents and another intervention to improve treatment adherence, whereas the control group (n=124) will only have an intervention to improve treatment adherence. We defined the primary outcome as the time to the first severe asthma exacerbation. Secondary outcomes will be number of exacerbations, time to the moderate exacerbation, changes in asthma quality-of-life and asthma control questionnaires, forced expiratory volume in 1 second (FEV1), Oxid Nitric Exhalated (eNO), use of relief medication and treatment adherence. Adults with a previous diagnostic of asthma, who had suffered ≥1 asthma exacerbation in the last year. Asthma, asthma exacerbation, environmental measures, allergens, irritants

Director: Orriols Martínez, Ramon
Sabater Talaverano, Gladis
Marcos-Gragera, Rafael
Altres contribucions: Universitat de Girona. Facultat de Medicina
Autor: Kolakowska, Natalia
Data: gener 2019
Resum: Asthma is one of the most common chronic diseases among the chronic respiratory disorders, affecting around 334 million people worldwide. Exposure to different allergens and irritants has been shown to be a major source of asthma exacerbations and worsening of asthma symptoms. Therefore, apart from the basal treatment, asthmatics can benefit from other non-pharmacological measures in order to avoid these proinflammatory agents. The main purpose of this project is to evaluate the effectiveness of an intervention on proinflammatory agents for asthma exacerbations and asthma control. It will be a prospective, multicentre, pragmatical, controlled, randomized, open-label clinical trial. Patients enrolled in this study will be randomized in two groups. The intervention group (n=124) will have an intervention in order to avoid proinflammatory agents and another intervention to improve treatment adherence, whereas the control group (n=124) will only have an intervention to improve treatment adherence. We defined the primary outcome as the time to the first severe asthma exacerbation. Secondary outcomes will be number of exacerbations, time to the moderate exacerbation, changes in asthma quality-of-life and asthma control questionnaires, forced expiratory volume in 1 second (FEV1), Oxid Nitric Exhalated (eNO), use of relief medication and treatment adherence. Adults with a previous diagnostic of asthma, who had suffered ≥1 asthma exacerbation in the last year. Asthma, asthma exacerbation, environmental measures, allergens, irritants
Format: application/pdf
Accés al document: http://hdl.handle.net/10256/16748
Llenguatge: eng
Col·lecció: Medicina (TFG)
Drets: Attribution-NonCommercial-NoDerivatives 4.0 International
URI Drets: http://creativecommons.org/licenses/by-nc-nd/4.0/
Matèria: Asma -- Tractament
Asthma -- Treatment
Al·lèrgia respiratòria -- Prevenció
Respiratory allergy -- Prevention
Títol: Impact of an intervention on proinflammatory agents in asthmatic patients
Tipus: info:eu-repo/semantics/bachelorThesis
Repositori: DUGiDocs

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