Item


Repetitive transcranial magnetic stimulation of orbitofrontal cortex for empathy enhancement in behavioural variant frontotemporal dementia: a randomized sham-controlled clinical trial to assess different intensities

Background Dementias are the leading cause of disability in later life and, due the aging of the population, are predicted to increase its burden. Frontotemporal dementia is the second cause of early onset dementia, before Alzheimer’s disease. Empathy loss is one of the core features of its behavioural variant, which impairs their social relationships and consequently reduces the quality of life of their familiars and caregivers. No therapy is approved for this dementia, and its management its mostly educational and symptomatic. Repetitive transcranial magnetic stimulation is a non- invasive, low-cost and available technique that is emerging as a potential therapeutic tool for multiple neurological and psychiatric conditions, showing potential to become a possibility to ameliorate social cognition deficits in these patients. Objectives The main purpose of this study is to test if repetitive transcranial magnetic stimulation, applied on the bilateral OFC in people suffering from behavioural variant frontotemporal dementia, could enhance empathy, comparing three different intensity parameters: sub-threshold, supra-threshold and sham stimulation. Secondary objectives include evaluating its effect on other cognitive areas and neuropsychiatric symptoms and improvement in caregivers quality of life; it will be assessed if atrophy degree interferes in the stimulation result and registered the tolerability and safety of the process. Design and Methods This study will be a randomized, single-blinded, multicentric, sham-controlled clinical trial. It will recruit 153 patients using a consecutive non-probabilistic method. Participants will be randomized in 3 arms following a 1:1:1 ratio; arm A) will receive subthreshold stimulation, arm B) suprathreshold stimulation and arm C) sham stimulation, for 4 consecutive weeks. Empathy will be assessed using Reading Mind in the Eyes test and Faux Pas test. Patients will be followed 1 year to assess therapy after-effects

Manager: Belchí Guillamón, Olga
Castells Cervelló, Xavier
Other contributions: Universitat de Girona. Facultat de Medicina
Author: Thió Casals, Júlia
Date: 2018 November
Abstract: Background Dementias are the leading cause of disability in later life and, due the aging of the population, are predicted to increase its burden. Frontotemporal dementia is the second cause of early onset dementia, before Alzheimer’s disease. Empathy loss is one of the core features of its behavioural variant, which impairs their social relationships and consequently reduces the quality of life of their familiars and caregivers. No therapy is approved for this dementia, and its management its mostly educational and symptomatic. Repetitive transcranial magnetic stimulation is a non- invasive, low-cost and available technique that is emerging as a potential therapeutic tool for multiple neurological and psychiatric conditions, showing potential to become a possibility to ameliorate social cognition deficits in these patients. Objectives The main purpose of this study is to test if repetitive transcranial magnetic stimulation, applied on the bilateral OFC in people suffering from behavioural variant frontotemporal dementia, could enhance empathy, comparing three different intensity parameters: sub-threshold, supra-threshold and sham stimulation. Secondary objectives include evaluating its effect on other cognitive areas and neuropsychiatric symptoms and improvement in caregivers quality of life; it will be assessed if atrophy degree interferes in the stimulation result and registered the tolerability and safety of the process. Design and Methods This study will be a randomized, single-blinded, multicentric, sham-controlled clinical trial. It will recruit 153 patients using a consecutive non-probabilistic method. Participants will be randomized in 3 arms following a 1:1:1 ratio; arm A) will receive subthreshold stimulation, arm B) suprathreshold stimulation and arm C) sham stimulation, for 4 consecutive weeks. Empathy will be assessed using Reading Mind in the Eyes test and Faux Pas test. Patients will be followed 1 year to assess therapy after-effects
Format: application/pdf
Document access: http://hdl.handle.net/10256/16766
Language: eng
Collection: Medicina (TFG)
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Rights URI: http://creativecommons.org/licenses/by-nc-nd/4.0/
Subject: Demència presenil -- Tractament
Presenile dementia -- Treatment
Cervell -- Estimulació
Brain stimulation
Empatia
Empathy
Title: Repetitive transcranial magnetic stimulation of orbitofrontal cortex for empathy enhancement in behavioural variant frontotemporal dementia: a randomized sham-controlled clinical trial to assess different intensities
Type: info:eu-repo/semantics/bachelorThesis
Repository: DUGiDocs

Subjects

Authors


Warning: Unknown: write failed: No space left on device (28) in Unknown on line 0

Warning: Unknown: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/var/lib/php5) in Unknown on line 0