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Van Eendenburg, Cecile
Marcos-Gragera, Rafael |
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Universitat de Girona. Facultat de Medicina | |
Sánchez MartÃnez, Anna | |
2023 January | |
BACKGROUND: Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive
neurodegenerative prion disease that affects the central nervous system. Although it has an
heterogeneous clinical presentation, the principal and most frequent clinical features are
progressive dementia, myoclonus or cerebellar manifestations as ataxia or nystagmus. It
has a challenging diagnostic as it requires clinical compatibility with a positive result of
another diagnostic tests such as real-time quaking-induced conversion (RT-QuIC) test,
14-3-3 protein cerebrospinal fluid (CSF) determination, magnetic resonance imaging (MRI) or
electroencephalogram (EEG) in order to achieve a probable sCJD diagnosis. From all these
tests, only RT-QuIC test and MRI can be abnormal at the beginning of the disease. For a
definitive sCJD diagnosis, a brain biopsy or a brain autopsy is needed for its
anatomopathological study. Nowadays, there is no curative available treatment for this
disease. However, some clinical assays and other studies have suggested promising results
for possible future curative treatments.
OBJECTIVE: The aim of this study is to evaluate the diagnostic accuracy of total tau (t-tau)
and phosphorylated-tau/total-tau (p-tau/t-tau) ratio combined with neurofilament light chain
protein (NfL) CSF biomarkers for the early diagnosis of patients with sCJD 3 |
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application/pdf | |
http://hdl.handle.net/10256/23070 | |
eng | |
Attribution-NonCommercial-NoDerivatives 4.0 International | |
http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
Creutzfeldt-Jakob, Malaltia de -- Diagnòstic
Creutzfeldt-Jakob disease -- Diagnosis Cervell -- Degeneració Brain -- Degeneration Sistema nerviós central Central nervous system Proteïnes Proteins Filaments citoplasmà tics Cytoplasmic filaments |
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Diagnostic accuracy of t-tau and tau ratio combined with neurofilaments for the early diagnosis of sporadic Creutzfeldt-Jakob disease: a multicentric analytical cross-sectional study | |
info:eu-repo/semantics/bachelorThesis | |
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