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Comparison of two weaning protocols in exremely and very preterm neonates with respiratory distress syndrome: a randomised, multicentre clinical trial

BACKGROUND: The most common complication of prematurity is the newborn respiratory distress syndrome. It is a pathology that mainly affects premature infants born before 32 weeks of gestation. About 40% of these neonates require invasive mechanical ventilation to manage the syndrome. Recently, it has been recognised that reducing intubation time and the number of reintubations is of great significance in reducing further complications. Therefore, one approach to decrease complications is to identify a weaning protocol that facilitates posterior extubation. OBJECTIVE: The main objective is to compare the number of reintubations of pressure support ventilation and assist control volume guarantee ventilation, in extremely and very preterm neonates with newborn respiratory distress syndrome with invasive mechanical ventilation. DESIGN: This study is designed as a randomized, open label, multicentrical clinical trial. It will be conducted in 5 different hospitals of Catalonia. PARTICIPANTS: 542 participants will be enrolled from 5 hospitals using a stratified consecutive sampling, and the time of recruitment will be approximately of 2 years and two months. These patients will be randomized in two groups, one for each weaning protocol, with a 1:1 ratio

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Director: Trujillo Fagundo, Alberto
​​Marcos-Gragera, Rafael
Altres contribucions: Universitat de Girona. Facultat de Medicina
Autor: Riu Pérez, Alba
Data: novembre 2023
Resum: BACKGROUND: The most common complication of prematurity is the newborn respiratory distress syndrome. It is a pathology that mainly affects premature infants born before 32 weeks of gestation. About 40% of these neonates require invasive mechanical ventilation to manage the syndrome. Recently, it has been recognised that reducing intubation time and the number of reintubations is of great significance in reducing further complications. Therefore, one approach to decrease complications is to identify a weaning protocol that facilitates posterior extubation. OBJECTIVE: The main objective is to compare the number of reintubations of pressure support ventilation and assist control volume guarantee ventilation, in extremely and very preterm neonates with newborn respiratory distress syndrome with invasive mechanical ventilation. DESIGN: This study is designed as a randomized, open label, multicentrical clinical trial. It will be conducted in 5 different hospitals of Catalonia. PARTICIPANTS: 542 participants will be enrolled from 5 hospitals using a stratified consecutive sampling, and the time of recruitment will be approximately of 2 years and two months. These patients will be randomized in two groups, one for each weaning protocol, with a 1:1 ratio
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Format: application/pdf
Accés al document: http://hdl.handle.net/10256/24679
Llenguatge: eng
Drets: Attribution-NonCommercial-NoDerivatives 4.0 International
URI Drets: http://creativecommons.org/licenses/by-nc-nd/4.0/
Matèria: Neonatologia
Neonatology
Infants prematurs
Premature babies
Aparell respiratori - Malalties en els infants
Pediatric respiratory diseases
Respiració artificial
Artificial respiration
Nodrissons - Deslletament
Infants - Weaning
Nodrissons
Infants
Títol: Comparison of two weaning protocols in exremely and very preterm neonates with respiratory distress syndrome: a randomised, multicentre clinical trial
Tipus: info:eu-repo/semantics/bachelorThesis
Repositori: DUGiDocs

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