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Breast cancer incidence and overdiagnosis in Catalonia (Spain)

Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to model invasive BC incidence trends in Catalonia (Spain) taking into account reproductive and screening data; and second, to quantify the extent of BC overdiagnosis. We modeled the incidence of invasive BC using a Poisson regression model. Explanatory variables were: age at diagnosis and cohort characteristics (completed fertility rate, percentage of women that use mammography at age 50, and year of birth). This model also was used to estimate the background incidence in the absence of screening. We used a probabilistic model to estimate the expected BC incidence if women in the population used mammography as reported in health surveys. The difference between the observed and expected cumulative incidences provided an estimate of overdiagnosis.Incidence of invasive BC increased, especially in cohorts born from 1940 to 1955. The biggest increase was observed in these cohorts between the ages of 50 to 65 years, where the final BC incidence rates more than doubled the initial ones. Dissemination of mammography was significantly associated with BC incidence and overdiagnosis. Our estimates of overdiagnosis ranged from 0.4% to 46.6%, for women born around 1935 and 1950, respectively.Our results support the existence of overdiagnosis in Catalonia attributed to mammography usage, and the limited malignant potential of some tumors may play an important role. Women should be better informed about this risk. Research should be oriented towards personalized screening and risk assessment tools

Breast Cancer Research, 2010, vol. 12, núm. 4, p. 58

BioMed Central

Author: Martínez-Alonso, Montserrat
Vilaprinyo, Ester
Marcos-Gragera, Rafael
Rué, Montserrat
Date: 2010
Abstract: Early detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to model invasive BC incidence trends in Catalonia (Spain) taking into account reproductive and screening data; and second, to quantify the extent of BC overdiagnosis. We modeled the incidence of invasive BC using a Poisson regression model. Explanatory variables were: age at diagnosis and cohort characteristics (completed fertility rate, percentage of women that use mammography at age 50, and year of birth). This model also was used to estimate the background incidence in the absence of screening. We used a probabilistic model to estimate the expected BC incidence if women in the population used mammography as reported in health surveys. The difference between the observed and expected cumulative incidences provided an estimate of overdiagnosis.Incidence of invasive BC increased, especially in cohorts born from 1940 to 1955. The biggest increase was observed in these cohorts between the ages of 50 to 65 years, where the final BC incidence rates more than doubled the initial ones. Dissemination of mammography was significantly associated with BC incidence and overdiagnosis. Our estimates of overdiagnosis ranged from 0.4% to 46.6%, for women born around 1935 and 1950, respectively.Our results support the existence of overdiagnosis in Catalonia attributed to mammography usage, and the limited malignant potential of some tumors may play an important role. Women should be better informed about this risk. Research should be oriented towards personalized screening and risk assessment tools
Format: application/pdf
Citation: Martinez-Alonso, M., Vilaprinyo, E., Marcos-Gragera, R., i Rue M. (2010). Breast cancer incidence and overdiagnosis in Catalonia (Spain). Breast Cancer Research, 12 (4), 58. Recuperat 22 juny de 2011, a http://breast-cancer-research.com/content/12/4/R58
Document access: http://hdl.handle.net/10256/3452
Language: eng
Publisher: BioMed Central
Collection: Articles publicats (D-I)
Is part of: Breast Cancer Research, 2010, vol. 12, núm. 4, p. 58
Rights: Aquest document està subjecte a una llicència idèntica a la ’Creative Commons: Reconeixement (by 2.0)’
Rights URI: http://www.biomedcentral.com/about/license
Subject: Mama -- Càncer
Mama -- Radiografia
Breast -- Cancer
Breast -- Radiography
Title: Breast cancer incidence and overdiagnosis in Catalonia (Spain)
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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