Ítem


Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas

Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread

New Journal of Physics, 2013, vol. 15, p. 055001

Institute of Physics

Autor: Fort, Joaquim
Sole, Ricard V.
Data: 2013
Resum: Glioblastomas are highly diffuse, malignant tumors that have so far evaded clinical treatment. The strongly invasive behavior of cells in these tumors makes them very resistant to treatment, and for this reason both experimental and theoretical efforts have been directed toward understanding the spatiotemporal pattern of tumor spreading. Although usual models assume a standard diffusion behavior, recent experiments with cell cultures indicate that cells tend to move in directions close to that of glioblastoma invasion, thus indicating that a biased random walk model may be much more appropriate. Here we show analytically that, for realistic parameter values, the speeds predicted by biased dispersal are consistent with experimentally measured data. We also find that models beyond reaction–diffusion–advection equations are necessary to capture this substantial effect of biased dispersal on glioblastoma spread
Format: application/pdf
ISSN: 1367-2630
Accés al document: http://hdl.handle.net/10256/8485
Llenguatge: eng
Editor: Institute of Physics
Col·lecció: Reproducció digital del document publicat a: http://dx.doi.org/10.1088/1367-2630/15/5/055001
Articles publicats (D-F)
És part de: New Journal of Physics, 2013, vol. 15, p. 055001
Drets: Attribution 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by/3.0/es/
Matèria: Gliomes
Gliomas
Tumors -- Models matemàtics
Tumors -- Mathematical models
Reaction-diffusion equations
Equacions de reacció-difusió
Títol: Accelerated tumor invasion under non-isotropic cell dispersal in glioblastomas
Tipus: info:eu-repo/semantics/article
Repositori: DUGiDocs

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