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Development of analytical methodologies for the determination of emerging contaminants and phosphorus compounds

The presence of anthropogenic chemical substances in water resources can affect the ecological balance of aquatic systems, as well as human health, and therefore it is necessary to control their presence in water bodies. The objective of this thesis is the development of analytical methodologies for the determination of phosphorus species and organic micropollutants in water samples. Firstly, two speciation methods for the determination of simple and condensate phosphorus oxoanions have been developed, using HPLC separation coupled to ICP-AES in one methodology and to ICP-MS in the other. Two analytical methodologies have been developed for the determination of endocrine disrupting compounds using PDMS rod extraction. The determination was carried out by GC-MS for flame retardants and by HPLC-DAD for phenolic compounds. Finally, a multiresidue method based on SPE followed by LC-MS/MS have been developed for the determination of 35 analytes, including pharmaceuticals, corrosion inhibitors, and pesticides, in water samples

La contaminaci贸 de l鈥檃igua per compostos d鈥檕rigen antropog猫nic pot afectar tant al medi ambient com a la salut humana i per tant 茅s necessari controlar-ne la pres猫ncia. L鈥檕bjectiu de la tesi 茅s desenvolupar metodologies anal铆tiques per a determinaci贸 de esp猫cies de f貌sfor i microcontaminants org脿nics en mostres d鈥檃igua. En primer lloc, s鈥檋an desenvolupat dos m猫todes d鈥檈speciaci贸 per a la determinaci贸 de oxoanions de f貌sfor simples i condensats, mitjan莽ant separaci贸 per HPLC acoblada a ICP-AES en un m猫tode, i a ICP-MS en l鈥檃ltre. Tamb茅 s鈥檋an desenvolupat dos m猫todes utilitzant extracci贸 amb cord贸 de PDMS per a la determinaci贸 de compostos que actuen com a disruptors endocrins. La determinaci贸 es va portar a terme per GC-MS per als retardants de flama bromats i per HPLC-DAD per als compostos fen貌lics. Finalment es va desenvolupar un m猫tode multiresidu basat en SPE seguit de LC-MS/MS per a la determinaci贸 de 35 analits, incloent compostos farmac猫utics, inhibidors de la corrosi贸 i plaguicides

Universitat de Girona

Manager: Salvad贸 Mart铆n, Vict貌ria
Iglesias Junc脿, M貌nica
Other contributions: Universitat de Girona. Departament de Qu铆mica
Author: Valls Cantenys, Carme
Date: 2014 November 21
Abstract: The presence of anthropogenic chemical substances in water resources can affect the ecological balance of aquatic systems, as well as human health, and therefore it is necessary to control their presence in water bodies. The objective of this thesis is the development of analytical methodologies for the determination of phosphorus species and organic micropollutants in water samples. Firstly, two speciation methods for the determination of simple and condensate phosphorus oxoanions have been developed, using HPLC separation coupled to ICP-AES in one methodology and to ICP-MS in the other. Two analytical methodologies have been developed for the determination of endocrine disrupting compounds using PDMS rod extraction. The determination was carried out by GC-MS for flame retardants and by HPLC-DAD for phenolic compounds. Finally, a multiresidue method based on SPE followed by LC-MS/MS have been developed for the determination of 35 analytes, including pharmaceuticals, corrosion inhibitors, and pesticides, in water samples
La contaminaci贸 de l鈥檃igua per compostos d鈥檕rigen antropog猫nic pot afectar tant al medi ambient com a la salut humana i per tant 茅s necessari controlar-ne la pres猫ncia. L鈥檕bjectiu de la tesi 茅s desenvolupar metodologies anal铆tiques per a determinaci贸 de esp猫cies de f貌sfor i microcontaminants org脿nics en mostres d鈥檃igua. En primer lloc, s鈥檋an desenvolupat dos m猫todes d鈥檈speciaci贸 per a la determinaci贸 de oxoanions de f貌sfor simples i condensats, mitjan莽ant separaci贸 per HPLC acoblada a ICP-AES en un m猫tode, i a ICP-MS en l鈥檃ltre. Tamb茅 s鈥檋an desenvolupat dos m猫todes utilitzant extracci贸 amb cord贸 de PDMS per a la determinaci贸 de compostos que actuen com a disruptors endocrins. La determinaci贸 es va portar a terme per GC-MS per als retardants de flama bromats i per HPLC-DAD per als compostos fen貌lics. Finalment es va desenvolupar un m猫tode multiresidu basat en SPE seguit de LC-MS/MS per a la determinaci贸 de 35 analits, incloent compostos farmac猫utics, inhibidors de la corrosi贸 i plaguicides
Format: application/pdf
Document access: http://hdl.handle.net/10803/284742
Language: eng
Publisher: Universitat de Girona
Rights: ADVERTIMENT. L鈥檃cc茅s als continguts d鈥檃questa tesi doctoral i la seva utilitzaci贸 ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, aix铆 com en activitats o materials d鈥檌nvestigaci贸 i doc猫ncia en els termes establerts a l鈥檃rt. 32 del Text Ref贸s de la Llei de Propietat Intel路lectual (RDL 1/1996). Per altres utilitzacions es requereix l鈥檃utoritzaci贸 pr猫via i expressa de la persona autora. En qualsevol cas, en la utilitzaci贸 dels seus continguts caldr脿 indicar de forma clara el nom i cognoms de la persona autora i el t铆tol de la tesi doctoral. No s鈥檃utoritza la seva reproducci贸 o altres formes d鈥檈xplotaci贸 efectuades amb finalitats de lucre ni la seva comunicaci贸 p煤blica des d鈥檜n lloc ali猫 al servei TDX. Tampoc s鈥檃utoritza la presentaci贸 del seu contingut en una finestra o marc ali猫 a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i 铆ndexs.
Subject: Qu铆mica org脿nica
Title: Development of analytical methodologies for the determination of emerging contaminants and phosphorus compounds
Type: doctoralThesis
Repository: TDX

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