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Comparing the effectiveness between fentanyl, remifentanil and propofol in preterm newborns undergoing INSURE procedure: a randomized controlled trial

Objectives: the aim of this study is to compare the effectivenessof fentanyl, remifentanil and propofol as a premedication forINSURE procedure, to treat preterm newborns suffering fromrespiratory distress syndrome (RDS)Design: non-placebo controlled, double blind, randomizedcontrolled clinical trial.Setting: multicenter clinical trial, involving 22 centers fromCatalonia and Madrid. Hospital Universitari Josep Trueta(Girona) will be the reference center.Participants: preterm newborns, below 32 GW or 1,500 gramsof birth weight, suffering from RDSInterventions: patients will be randomized in three groups andeach group will receive one of the three premedications.Secondly they will undergo INSURE procedure, response andadverse effects will be recorded. Infants will be followed-upduring two years, and long-term effects development will becollected.Main outcome measures: primary outcome measure is the timeto succesful extubation. Secondary outcome measures includeappearance of complications during the procedure, anddevelopment long-term secondary effects

Facultat de Medicina

Director: Sánchez Fernández, Mario
Altres contribucions: Universitat de Girona. Facultat de Medicina
Autor: Baró Giró, Adriana
Resum: Objectives: the aim of this study is to compare the effectivenessof fentanyl, remifentanil and propofol as a premedication forINSURE procedure, to treat preterm newborns suffering fromrespiratory distress syndrome (RDS)Design: non-placebo controlled, double blind, randomizedcontrolled clinical trial.Setting: multicenter clinical trial, involving 22 centers fromCatalonia and Madrid. Hospital Universitari Josep Trueta(Girona) will be the reference center.Participants: preterm newborns, below 32 GW or 1,500 gramsof birth weight, suffering from RDSInterventions: patients will be randomized in three groups andeach group will receive one of the three premedications.Secondly they will undergo INSURE procedure, response andadverse effects will be recorded. Infants will be followed-upduring two years, and long-term effects development will becollected.Main outcome measures: primary outcome measure is the timeto succesful extubation. Secondary outcome measures includeappearance of complications during the procedure, anddevelopment long-term secondary effects
Accés al document: http://hdl.handle.net/2072/266003
Llenguatge: eng
Editor: Facultat de Medicina
Drets: Attribution-NonCommercial-NoDerivs 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Matèria: Infants prematurs -- Aparell respiratori
Infants (premature) -- Respiratory organs
Títol: Comparing the effectiveness between fentanyl, remifentanil and propofol in preterm newborns undergoing INSURE procedure: a randomized controlled trial
Tipus: info:eu-repo/semantics/bachelorThesis
Repositori: Recercat

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