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Comparing the effectiveness between fentanyl, remifentanil and propofol in preterm newborns undergoing INSURE procedure: a randomized controlled trial

Objectives: the aim of this study is to compare the effectivenessof fentanyl, remifentanil and propofol as a premedication forINSURE procedure, to treat preterm newborns suffering fromrespiratory distress syndrome (RDS)Design: non-placebo controlled, double blind, randomizedcontrolled clinical trial.Setting: multicenter clinical trial, involving 22 centers fromCatalonia and Madrid. Hospital Universitari Josep Trueta(Girona) will be the reference center.Participants: preterm newborns, below 32 GW or 1,500 gramsof birth weight, suffering from RDSInterventions: patients will be randomized in three groups andeach group will receive one of the three premedications.Secondly they will undergo INSURE procedure, response andadverse effects will be recorded. Infants will be followed-upduring two years, and long-term effects development will becollected.Main outcome measures: primary outcome measure is the timeto succesful extubation. Secondary outcome measures includeappearance of complications during the procedure, anddevelopment long-term secondary effects

Facultat de Medicina

Manager: Sánchez Fernández, Mario
Other contributions: Universitat de Girona. Facultat de Medicina
Author: Baró Giró, Adriana
Abstract: Objectives: the aim of this study is to compare the effectivenessof fentanyl, remifentanil and propofol as a premedication forINSURE procedure, to treat preterm newborns suffering fromrespiratory distress syndrome (RDS)Design: non-placebo controlled, double blind, randomizedcontrolled clinical trial.Setting: multicenter clinical trial, involving 22 centers fromCatalonia and Madrid. Hospital Universitari Josep Trueta(Girona) will be the reference center.Participants: preterm newborns, below 32 GW or 1,500 gramsof birth weight, suffering from RDSInterventions: patients will be randomized in three groups andeach group will receive one of the three premedications.Secondly they will undergo INSURE procedure, response andadverse effects will be recorded. Infants will be followed-upduring two years, and long-term effects development will becollected.Main outcome measures: primary outcome measure is the timeto succesful extubation. Secondary outcome measures includeappearance of complications during the procedure, anddevelopment long-term secondary effects
Document access: http://hdl.handle.net/2072/266003
Language: eng
Publisher: Facultat de Medicina
Rights: Attribution-NonCommercial-NoDerivs 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Subject: Infants prematurs -- Aparell respiratori
Infants (premature) -- Respiratory organs
Title: Comparing the effectiveness between fentanyl, remifentanil and propofol in preterm newborns undergoing INSURE procedure: a randomized controlled trial
Type: info:eu-repo/semantics/bachelorThesis
Repository: Recercat

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