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Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity

Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use

Nature Publishing Group

Autor: Fagundo, Ana B.
Jiménez Murcia, Susana
Giner Bartolomé, C.
Agüera, Zaida
Sauchelli, S.
Pardo, M.
Crujeiras, Ana B.
Granero, Roser
Baños, Rosa M.
Botella, Cristina
Torre, Rafael de la
Fernández-Real Lemos, José Manuel
Fernández García, Jose C.
Frühbeck, Gema
Rodríguez, Amaia
Mallorquí Bagué, Nuria
Tárrega, S.
Tinahones, Francisco J.
Rodriguez, R.
Ortega, F.
Menchón, José Manuel
Casanueva, Felipe F.
Fernández Aranda, Fernando
Resum: Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use
Accés al document: http://hdl.handle.net/2072/285699
Llenguatge: eng
Editor: Nature Publishing Group
Drets: Attribution 4.0 Spain
URI Drets: http://creativecommons.org/licenses/by/4.0/es/
Matèria: Obesitat -- Tractament
Obesity -- Treatment
Obesitat mòrbida -- Tractament
Morbid obesity -- Treatment
Títol: Modulation of Irisin and Physical Activity on Executive Functions in Obesity and Morbid obesity
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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