DUGi

Obesity changes the human gut mycobiome

http://dugi.udg.edu/item/http:@@@@hdl.handle.net@@2072@@289416

The human intestine is home to a diverse range of bacterial and fungal species, forming anecological community that contributes to normal physiology and disease susceptibility. Here, thefungal microbiota (mycobiome) in obese and non-obese subjects was characterized using InternalTranscribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could bediscriminated by their specific fungal composition, which also distinguished metabolically “healthy”from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness,fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioicacid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus werethe species more represented in non-obese subjects compared to obese counterparts. Interestingly,the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weightloss. Collectively, these findings suggest that manipulation of gut mycobiome communities might bea novel target in the treatment of obesity

Nature Publishing Group