Item


Obesity changes the human gut mycobiome

The human intestine is home to a diverse range of bacterial and fungal species, forming anecological community that contributes to normal physiology and disease susceptibility. Here, thefungal microbiota (mycobiome) in obese and non-obese subjects was characterized using InternalTranscribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could bediscriminated by their specific fungal composition, which also distinguished metabolically “healthy”from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness,fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioicacid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus werethe species more represented in non-obese subjects compared to obese counterparts. Interestingly,the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weightloss. Collectively, these findings suggest that manipulation of gut mycobiome communities might bea novel target in the treatment of obesity

Nature Publishing Group

Author: Rodríguez, M. Mar
Pérez, Daniel
Chaves, Felipe Javier
Esteve, Eduardo
Marin-Garcia, Pablo
Xifra Vilarroya, Gemma
Vendrell, Joan
Jové, Mariona
Pamplona, Reinald
Ricart, Wifredo
Portero Otin, Manuel
Chacón, Matilde R.
Fernández-Real Lemos, José Manuel
Abstract: The human intestine is home to a diverse range of bacterial and fungal species, forming anecological community that contributes to normal physiology and disease susceptibility. Here, thefungal microbiota (mycobiome) in obese and non-obese subjects was characterized using InternalTranscribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could bediscriminated by their specific fungal composition, which also distinguished metabolically “healthy”from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness,fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioicacid, caproic acid and N-acetyl-L-glutamic acid was also found. Mucor racemosus and M. fuscus werethe species more represented in non-obese subjects compared to obese counterparts. Interestingly,the decreased relative abundance of the Mucor genus in obese subjects was reversible upon weightloss. Collectively, these findings suggest that manipulation of gut mycobiome communities might bea novel target in the treatment of obesity
Document access: http://hdl.handle.net/2072/289416
Language: eng
Publisher: Nature Publishing Group
Rights: Attribution 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by/3.0/es/
Subject: Intestins -- Microbiologia
Intestines -- Microbiology
Intestins -- Malalties
Intestines -- Diseases
Persones obeses
Overweight persons
Title: Obesity changes the human gut mycobiome
Type: info:eu-repo/semantics/article
Repository: Recercat

Subjects

Authors


Warning: Unknown: write failed: No space left on device (28) in Unknown on line 0

Warning: Unknown: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/var/lib/php5) in Unknown on line 0