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The dynamic behaviour of metabolic syndrome and its components in an eightyear population-based cohort from the Mediterranean

The significant rise in the prevalence of obesity coincides with the considerable increase inthe prevalence of metabolic syndrome (MS) currently being observed worldwide. The componentsof MS are not static and their dynamics, such as the order of their occurrence, orthe time of exposure to them are, as yet, unknown but could well be clinically relevant. Ourobjective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region.Methods and findingsOur study employed a retrospective cohort (between January 1, 2005 and December 31,2012) made up of individuals from the general population in a region in the northeast of Catalonia,Spain. Given that most of the explicative variables of the risk of having MS were timedependent and, therefore, the risk was not proportional, we used the Andersen-Gill (AG)model to perform a multivariate survival analysis and inferences were performed using aBayesian framework.Thirty-nine percent of the participants developed MS; 44.6% of them with a single limitedepisode. Triglycerides and low HDL cholesterol, together with obesity, are componentsassociated with the first occurrence of MS. Components related to the metabolism of glucoseare associated with a medium risk of having a first episode of MS, and those related toblood pressure are associated with a lower risk. When the components related to bloodpressure and the metabolism of glucose appear first, they determine the appearance of thefirst episode of MS. The variables concerning the persistence of MS are those that correspondto clinical conditions that do not have well-established drug treatment criteria. ConclusionsOur results suggest that the components related to the metabolism of glucose and to highblood pressure appear early on and act as biomarkers for predicting MS, while the componentsrelated to obesity and dyslipidaemia, although essential for the development of MS, appearlater. Making lifestyle changes reduces the conditions associated with the persistence of MS

Public Library of Science (PLoS)

Autor: Barceló Rado, María Antonia
Rodríguez Poncelas, Antonio
Sáez Zafra, Marc
Coll de Tuero, Gabriel
Resum: The significant rise in the prevalence of obesity coincides with the considerable increase inthe prevalence of metabolic syndrome (MS) currently being observed worldwide. The componentsof MS are not static and their dynamics, such as the order of their occurrence, orthe time of exposure to them are, as yet, unknown but could well be clinically relevant. Ourobjective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region.Methods and findingsOur study employed a retrospective cohort (between January 1, 2005 and December 31,2012) made up of individuals from the general population in a region in the northeast of Catalonia,Spain. Given that most of the explicative variables of the risk of having MS were timedependent and, therefore, the risk was not proportional, we used the Andersen-Gill (AG)model to perform a multivariate survival analysis and inferences were performed using aBayesian framework.Thirty-nine percent of the participants developed MS; 44.6% of them with a single limitedepisode. Triglycerides and low HDL cholesterol, together with obesity, are componentsassociated with the first occurrence of MS. Components related to the metabolism of glucoseare associated with a medium risk of having a first episode of MS, and those related toblood pressure are associated with a lower risk. When the components related to bloodpressure and the metabolism of glucose appear first, they determine the appearance of thefirst episode of MS. The variables concerning the persistence of MS are those that correspondto clinical conditions that do not have well-established drug treatment criteria. ConclusionsOur results suggest that the components related to the metabolism of glucose and to highblood pressure appear early on and act as biomarkers for predicting MS, while the componentsrelated to obesity and dyslipidaemia, although essential for the development of MS, appearlater. Making lifestyle changes reduces the conditions associated with the persistence of MS
Accés al document: http://hdl.handle.net/2072/289421
Llenguatge: eng
Editor: Public Library of Science (PLoS)
Drets: Attribution 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by/3.0/es/
Matèria: Síndrome metabòlica
Metabolic syndrome
Metabolisme -- Trastorns
Metabolism -- Disorders
Títol: The dynamic behaviour of metabolic syndrome and its components in an eightyear population-based cohort from the Mediterranean
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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