DUGi

Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study

http://dugi.udg.edu/item/http:@@@@hdl.handle.net@@2072@@289422

Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primaryaim of this study was to investigate the relationship of fasting plasma glucose (FPG),postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulsewave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. Thesecondary aim was to analyse this relationship by glycaemic status.MethodsCross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35±74 years.Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automatedenzymatic methods. PG (mg/dL) was self-measured at home two hours after meals(breakfast, lunch and dinner) for one day using an Accu-chek ® glucometer. CAVI was measuredusing a VaSera VS-1500® device (Fukuda Denshi), and baPWV was calculated usinga validated equation.ResultsCAVI and baPWV values were significantly higher in subjects with diabetes mellitus than inglucose normal and prediabetes groups (p<0.001). FPG, PG and HbA1c were positivelyassociated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 (CI 95% 0.068 to 0.155) with CAVI, 0.266 (CI 95% 0.172 to 0.359) with baPWV; for PG was0.006 (CI 95% 0.004 to 0.009 and for FPG was 0.005 (CI 95% 0.002 to 0.008) with baPWV;and for PG was 0.002 (CI 95% 0.001 to 0.003) and 0.003 (CI 95% 0.002 to 0.004) with CAVI(p<0.01 in all cases). When analysing by hyperglycaemic status, FPG, PG and HbA1c werepositively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus.ConclusionFPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasianadults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status,the association is only maintained in subjects with type 2 diabetes mellitus

Public Library of Science (PLoS)