DUGi

The iron (II) complex [Fe(CF3SO3)2(mcp)] as a convenient, readily available catalyst for the selective oxidation of methylenic sites in alkanes

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The efficient and selective oxidation of secondary C-H sites of alkanes is achieved by using low catalyst loadings of a non-expensive, readily available iron catalyst [Fe(II)(CF3SO3)2(mcp)], {Fe-mcp, [mcp=N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)cyclohexane-trans-1,2-diamine]}, and hydrogen peroxide (H2O2) as oxidant, via a simple reaction protocol. Natural products are selectively oxidized and isolated in synthetically amenable yields. The easy access to large quantities of the catalyst and the simplicity of the C-H oxidation procedure make this system a particularly convenient tool to carry out alkane C-H oxidation reactions on the preparative scale, and in short reaction times

We would like to thank European Research Foundation for Project ERC-2009-StG-239910, MICINN for projects CTQ2012-37420-C02-01/BQU and CSD2010-00065. Generalitat de Catalunya for an ICREA Academia Award (X. R. and M. C.) and PhD grant (M. Canta). X. R. thanks financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1

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