Item


Structural modeling of iron halogenases: Synthesis and reactivity of halide-iron(iv)-oxo compounds

A structural synthetic model of the iron(IV)-oxo-halide active species of non-heme iron dependent halogenases is reported. Compounds with general formula [FeIV(O)(X)(Pytacn)]+ (1-X, X = Cl, Br) have been prepared and characterized spectroscopically and chemically with regard to their oxidizing ability. 1-X performs hydrogen-atom abstraction of C–H bonds at reaction rates 2–3 times faster than the corresponding solvato dicationic species, thus modelling the first step in C–H functionalization taking place in natural halogenation

The authors acknowledge the European Commission for project FP7-PEOPLE-2011-CIG-303522 (A.C.), the European Research Council for project ERC-009StG-239910 (M.C.), Generalitat de Catalunya for an ICREA Academia Award (M.C.) and a predoctoral FI fellowship to O.P., and the SpanishMinistry of Science for project CTQ2012-37420-C02-01/BQU (M.C.) and a Ramon y Cajal contract to A.C. J.-M.L. acknowledges the support, in part, of Labex ARCANE (ANR-11-LABX-0003-01). We thank Catexel for a generous gift of tritosyl-1,4,7-triazacyclononane. We are grateful for financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1 to Dr X. Ribas

Royal Society of Chemistry (RSC)

Manager: European Research Council
Ministerio de Economía y Competitividad (Espanya)
Ministerio de Ciencia e Innovación (Espanya)
Author: Planas Fàbrega, Oriol
Clémancey, Martin
Latour, Jean Marc
Company Casadevall, Anna
Costas Salgueiro, Miquel
Abstract: A structural synthetic model of the iron(IV)-oxo-halide active species of non-heme iron dependent halogenases is reported. Compounds with general formula [FeIV(O)(X)(Pytacn)]+ (1-X, X = Cl, Br) have been prepared and characterized spectroscopically and chemically with regard to their oxidizing ability. 1-X performs hydrogen-atom abstraction of C–H bonds at reaction rates 2–3 times faster than the corresponding solvato dicationic species, thus modelling the first step in C–H functionalization taking place in natural halogenation
The authors acknowledge the European Commission for project FP7-PEOPLE-2011-CIG-303522 (A.C.), the European Research Council for project ERC-009StG-239910 (M.C.), Generalitat de Catalunya for an ICREA Academia Award (M.C.) and a predoctoral FI fellowship to O.P., and the SpanishMinistry of Science for project CTQ2012-37420-C02-01/BQU (M.C.) and a Ramon y Cajal contract to A.C. J.-M.L. acknowledges the support, in part, of Labex ARCANE (ANR-11-LABX-0003-01). We thank Catexel for a generous gift of tritosyl-1,4,7-triazacyclononane. We are grateful for financial support from INNPLANTA project INP-2011-0059-PCT-420000-ACT1 to Dr X. Ribas
Document access: http://hdl.handle.net/2072/296131
Language: eng
Publisher: Royal Society of Chemistry (RSC)
Rights: Tots els drets reservats
Subject: Ferro -- Compostos
Iron compounds
Oxidació
Oxidation
Title: Structural modeling of iron halogenases: Synthesis and reactivity of halide-iron(iv)-oxo compounds
Type: info:eu-repo/semantics/article
Repository: Recercat

Subjects

Authors


Warning: Unknown: write failed: No space left on device (28) in Unknown on line 0

Warning: Unknown: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (/var/lib/php5) in Unknown on line 0