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Why do cycloaddition reactions involving C60 prefer [6,6] over [5,6] bonds?

The origin of the experimentally known preference for [6,6] over [5,6] bonds in cycloaddition reactions involving C60 has been computationally explored. To this end, the Diels-Alder reaction between cyclopentadiene and C60 has been analysed by means of the recently introduced activation strain model of reactivity in combination with the energy decomposition analysis method. Other issues, such as the aromaticity of the corresponding transition states, have also been considered. These results indicate that the major factor controlling the observed regioselectivity is the more stabilising interaction between the deformed reactants in the [6,6] reaction pathway along the entire reaction coordinate. Why [6,6]? The preference for [6,6] over [5,6] bonds in cycloaddition reactions involving C60 is experimentally well-established (see figure). However, the reasons (i.e., physical factors) behind this preference are so far completely unknown. By means of the recently introduced activation strain model of reactivity in combination with the energy decomposition analysis method, a definite answer to the question in the title is provided

We are grateful for financial support from the Spanish MICINN (grants CTQ2010-20714-C02-01, Consolider-Ingenio 2010, and CSD2007-00006 to I. F. and CTQ2011-23156/BQU to M. S.), CAM (grant S2009/PPQ-1634 to I. F.), Catalan DIUE (projects 2009SGR637 and XRQTC to M. S.), the FEDER fund for the grant UNGI08-4E-003 to M. S., the National Research School Combination-Catalysis (NRSC-C), and The Netherlands Organization for Scientific Research (NWO/CW and NWO/NCF). Support for the research of M. S. was received through the ICREA Academia 2009 prize of the Catalan DIUE

Wiley-VCH Verlag

Manager: Ministerio de Ciencia e Innovación (Espanya)
Generalitat de Catalunya. Agència de Gestió d’Ajuts Universitaris i de Recerca
Author: Fenández López, Israel
Solà i Puig, Miquel
Bickelhaupt, F. Matthias
Abstract: The origin of the experimentally known preference for [6,6] over [5,6] bonds in cycloaddition reactions involving C60 has been computationally explored. To this end, the Diels-Alder reaction between cyclopentadiene and C60 has been analysed by means of the recently introduced activation strain model of reactivity in combination with the energy decomposition analysis method. Other issues, such as the aromaticity of the corresponding transition states, have also been considered. These results indicate that the major factor controlling the observed regioselectivity is the more stabilising interaction between the deformed reactants in the [6,6] reaction pathway along the entire reaction coordinate. Why [6,6]? The preference for [6,6] over [5,6] bonds in cycloaddition reactions involving C60 is experimentally well-established (see figure). However, the reasons (i.e., physical factors) behind this preference are so far completely unknown. By means of the recently introduced activation strain model of reactivity in combination with the energy decomposition analysis method, a definite answer to the question in the title is provided
We are grateful for financial support from the Spanish MICINN (grants CTQ2010-20714-C02-01, Consolider-Ingenio 2010, and CSD2007-00006 to I. F. and CTQ2011-23156/BQU to M. S.), CAM (grant S2009/PPQ-1634 to I. F.), Catalan DIUE (projects 2009SGR637 and XRQTC to M. S.), the FEDER fund for the grant UNGI08-4E-003 to M. S., the National Research School Combination-Catalysis (NRSC-C), and The Netherlands Organization for Scientific Research (NWO/CW and NWO/NCF). Support for the research of M. S. was received through the ICREA Academia 2009 prize of the Catalan DIUE
Document access: http://hdl.handle.net/2072/296684
Language: eng
Publisher: Wiley-VCH Verlag
Rights: Tots els drets reservats
Subject: Reaccions d’addició
Addition reactions
Funcional de densitat, Teoria del
Density functionals
Diels-Alder, Reacció de
Diels-Alder reaction
Fullerenes
Ful·lerens
Ciclització (Química)
Ring formation (Chemistry)
Title: Why do cycloaddition reactions involving C60 prefer [6,6] over [5,6] bonds?
Type: info:eu-repo/semantics/article
Repository: Recercat

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