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Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine

The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans

This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)

American Society for Microbiology

Manager: Ministerio de Ciencia e Innovación (Espanya)
Author: Martínez Medina, Margarita
Garcia-Gil, L. J.
Barnich, Nicolas
Wieler, Lothar H.
Ewers, Christa
Abstract: The adherent-invasive Escherichia coli (AIEC) pathotype, which has been associated with Crohn’s disease, shows similar traits to human and animal extraintestinal pathogenic E. coli (ExPEC) with respect to their phylogenetic origin and virulence gene profiles. Here, we demonstrate that animal ExPEC strains generally do not share the AIEC phenotype. In contrast, this phenotype is very frequent among animal intestinal pathogenic E. coli (InPEC) strains, particularly of feline and canine origin, that genetically resemble ExPEC. These results strengthen the particular identity and disease specificity of the AIEC pathotype and the putative role animals might play in the transmission of AIEC-like strains to humans
This work was funded by the Spanish Ministry of Education and Science (SAF2010-15896) and supported by the ANR in the frame of ERA-NET Pathogenomics and from the Deutsche Forschungsgemeinschaft (German Research Foundation; WI 1436/5-3)
Document access: http://hdl.handle.net/2072/296961
Language: eng
Publisher: American Society for Microbiology
Rights: Tots els drets reservats
Subject: Intestins -- Inflamació
Inflammatory bowel diseases
Crohn, Malaltia de
Crohn’s disease
Infeccions per escheríchia coli
Escherichia coli infections
Title: Adherent-invasive Escherichia coli phenotype displayed by intestinal pathogenic E. coli strains from cats, dogs, and swine
Type: info:eu-repo/semantics/article
Repository: Recercat

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