Item
Santos, Sónia Sá
Santos, Sara Matos Pinto, Antónia R T Ramu, Vasanthakumar Ganga Heras i Corominas, Montserrat Bardajà RodrÃguez, Eduard Tavares, Isaura R. Castanho, Miguel Augusto Rico Botas |
|
Chronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer’s disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP) is an endogenous antinociceptive dipeptide whose role as neuromodulator/neuroprotector has been suggested. Recently, we designed two analgesic KTP-derivatives, KTP-amide (KTP–NH2) and KTP–NH2 linked to ibuprofen (IbKTP–NH2) to improve KTP brain targeting. This study investigated the effects of KTP-derivatives on cognitive/behavioral functions (motor/spatial memory/nociception) and hippocampal pathology of female rats in chronic cerebral hypoperfusion (2VO-rat model). 2VO-animals were treated with KTP–NH2 or IbKTP–NH2 for 7 days at weeks 2 and 5 post-surgery. After behavioral testing (week 6), coronal sections of hippocampus were H&E-stained or immunolabeled for the cellular markers GFAP (astrocytes) and NFL (neurons). Our findings show that KTP-derivatives, mainly IbKTP–NH2, enhanced cognitive impairment of 2VO-animals and prevented neuronal damage in hippocampal CA1 subfield, suggesting their potential usefulness for the treatment of dementia | |
http://hdl.handle.net/2072/297782 | |
eng | |
Frontiers Media | |
Attribution 3.0 Spain | |
http://creativecommons.org/licenses/by/3.0/es/ | |
Demència -- Tractament
Dementia -- Treatment Farmacologia experimental Experimental psychopharmacology |
|
Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model | |
info:eu-repo/semantics/article | |
Recercat |