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DUGi: Ítem | Recercat - Quantitative profiling of perfluoroalkyl substances by ultrahigh-performance liquid chromatography and hybrid quadrupole time-of-flight mass spectrometry

Ítem


Quantitative profiling of perfluoroalkyl substances by ultrahigh-performance liquid chromatography and hybrid quadrupole time-of-flight mass spectrometry

The accurate determination of perfluoroalkyl substances(PFSAs) in water, sediment, fish, meat, and human milk was achieved by ultrahigh-performance liquid chromatography– quadrupole time-of-flight mass spectrometry (UHPLC–QqTOF-MS) with an ABSciex Triple TOF®. A group of 21 PFSAs was selected as target to evaluate the quantitative possibilities. Full scan MS acquisition data allows quantification at relevant low levels (0.1–50 ng L−1 in water, 0.05–2 ng g−1 in sediments, 0.01–5 ng g−1 in fish and meat, and 0.005–2 ng g−1 in human milk depending on the compound). Automatic information dependent acquisition product ion mass spectrometry (IDA-MS/MS) confirms the identity even for those compounds that presented only one product ion. The preparation of a homemade database using the extracted ion chromatogram (XIC) Manager of the software based upon retention time, accurate mass, isotopic pattern, and MS/MS library searching achieves not only the successful identification of PFSAs but also of some pharmaceuticals, such as acetaminophen, ibuprofen, salicylic acid, and gemfibrozid. Mean recoveries and relative standard deviation (RSD) were 67–99% (9–16% RSD) for water, 62–103 % (8– 18 % RSD) for sediment, 60–95 % (8–17 % RSD) for fish, 64–95 % (8–15 % RSD) for meat, and 63–95 % (8–16 %) for human milk. The quantitative data obtained for 60 samples by UHPLC–QqTOF-MS agree with those obtained by LC–MS/MS with a triple quadrupole (QqQ)

This work has been supported by the SpanishMinistry of Economy and Competitiveness through the projects BAssessing and predicting effects on water quantity and quality in Iberian rivers caused by global change (SCARCE)^ (No. CSD2009-00065, http:// www.scarceconsolider.es) and BEvaluation of emerging contaminants in the Turia River Basins: from basic research to the application of environmental forensics (EMERFOR)^ (GCL2011-29703-C02-02, http://mefturia.es)

Springer Verlag

Director: Ministerio de Ciencia e Innovación (Espanya)
Autor: Picó, Yolanda
Farré, Marinella
Barceló i Cullerés, Damià
Resum: The accurate determination of perfluoroalkyl substances(PFSAs) in water, sediment, fish, meat, and human milk was achieved by ultrahigh-performance liquid chromatography– quadrupole time-of-flight mass spectrometry (UHPLC–QqTOF-MS) with an ABSciex Triple TOF®. A group of 21 PFSAs was selected as target to evaluate the quantitative possibilities. Full scan MS acquisition data allows quantification at relevant low levels (0.1–50 ng L−1 in water, 0.05–2 ng g−1 in sediments, 0.01–5 ng g−1 in fish and meat, and 0.005–2 ng g−1 in human milk depending on the compound). Automatic information dependent acquisition product ion mass spectrometry (IDA-MS/MS) confirms the identity even for those compounds that presented only one product ion. The preparation of a homemade database using the extracted ion chromatogram (XIC) Manager of the software based upon retention time, accurate mass, isotopic pattern, and MS/MS library searching achieves not only the successful identification of PFSAs but also of some pharmaceuticals, such as acetaminophen, ibuprofen, salicylic acid, and gemfibrozid. Mean recoveries and relative standard deviation (RSD) were 67–99% (9–16% RSD) for water, 62–103 % (8– 18 % RSD) for sediment, 60–95 % (8–17 % RSD) for fish, 64–95 % (8–15 % RSD) for meat, and 63–95 % (8–16 %) for human milk. The quantitative data obtained for 60 samples by UHPLC–QqTOF-MS agree with those obtained by LC–MS/MS with a triple quadrupole (QqQ)
This work has been supported by the SpanishMinistry of Economy and Competitiveness through the projects BAssessing and predicting effects on water quantity and quality in Iberian rivers caused by global change (SCARCE)^ (No. CSD2009-00065, http:// www.scarceconsolider.es) and BEvaluation of emerging contaminants in the Turia River Basins: from basic research to the application of environmental forensics (EMERFOR)^ (GCL2011-29703-C02-02, http://mefturia.es)
Accés al document: http://hdl.handle.net/2072/297936
Llenguatge: eng
Editor: Springer Verlag
Drets: Tots els drets reservats
Matèria: Medicaments -- Aspectes ambientals
Drugs -- Environmental aspects
Cromatografia de líquids
Liquid chromatography
Espectrometria de masses
Mass spectrometry
Contaminants emergents en l’aigua
Emerging contaminants in water
Títol: Quantitative profiling of perfluoroalkyl substances by ultrahigh-performance liquid chromatography and hybrid quadrupole time-of-flight mass spectrometry
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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