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An Enantioselective Cascade Cyclopropanation Reaction Catalyzed by Rhodium(I): Asymmetric Synthesis of Vinylcyclopropanes

N-Tosylhydrazone-yne-ene substrates are satisfactorily prepared and their cyclization under rhodium catalysis is evaluated. A cascade process involving rhodium vinyl carbene formation – through carbene/alkyne metathesis – and cyclopropanation has been developed to stereoselectively afford vinylcyclopropanes

We are grateful for the financial support by the Spanish Ministry of Education and Science (MINECO) (Project CTQ2014-54306-P) and the DIUE of the Generalitat de Catalunya (Project 2014-SGR-931 and FI predoctoral grant to >.T.)

Wiley

Manager: Ministerio de Economía y Competitividad (Espanya)
Author: Torres Antón, Òscar
Roglans i Ribas, Anna
Pla i Quintana, Anna
Abstract: N-Tosylhydrazone-yne-ene substrates are satisfactorily prepared and their cyclization under rhodium catalysis is evaluated. A cascade process involving rhodium vinyl carbene formation – through carbene/alkyne metathesis – and cyclopropanation has been developed to stereoselectively afford vinylcyclopropanes
We are grateful for the financial support by the Spanish Ministry of Education and Science (MINECO) (Project CTQ2014-54306-P) and the DIUE of the Generalitat de Catalunya (Project 2014-SGR-931 and FI predoctoral grant to >.T.)
Document access: http://hdl.handle.net/2072/298898
Language: eng
Publisher: Wiley
Rights: Tots els drets reservats
Subject: Ciclització (Química)
Ring formation (Chemistry)
Carbens
Carbenes (Methylene compounds)
Ciclopropà
Cyclopropane
Catàlisi asimètrica
Enantioselective catalysis
Rodi
Rhodium
Title: An Enantioselective Cascade Cyclopropanation Reaction Catalyzed by Rhodium(I): Asymmetric Synthesis of Vinylcyclopropanes
Type: info:eu-repo/semantics/article
Repository: Recercat

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