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One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)

The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33Â % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure

Springer Verlag

Autor: Zeljenková, Dagmar
Aláčová, Radka
Ondrejková, Júlia
Ambrušová, Katarína
Bartušová, Mária
Kebis, Anton
Kovrižnych, Jevgenij
Rollerová, Eva
Szabová, Elena
Wimmerová, Soňa
Černák, Martin
Krivošíková, Zora
Kuricová, Miroslava
Líšková, Aurélia
Spustová, Viera
Tulinská, Jana
Levkut, Mikuláš
Révajová, Viera
Ševčíková, Zuzana
Schmidt, Kerstin
Schmidtke, Jörg
Schmidt, Paul
La Paz, Jose Luis
Corujo, Maria
Pla i de Solà-Morales, Maria
Kleter, Gijs A.
Kok, Esther J.
Sharbati, Jutta
Bohmer, Marc
Bohmer, Nils
Einspanier, Ralf
Adel-Patient, Karine
Spök, Armin
Pöting, Annette
Kohl, Christian
Wilhelm, Ralf
Schiemann, Joachim
Steinberg, Pablo
Resum: The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33Â % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure
Accés al document: http://hdl.handle.net/2072/299012
Llenguatge: eng
Editor: Springer Verlag
Drets: Attribution 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by/3.0/es/
Matèria: Plantes transgèniques
Transgenic plants
Enginyeria genètica vegetal
Plant genetic engineering
Blat de moro -- Genètica
Corn -- Genetics
Títol: One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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