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DUGi: Ítem | Recercat - Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond

Ítem


Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond

The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr1 and a d-Tyr7 led to the most stable sequences

This work was financed by Grant AGL2012-39880-C02-02

American Chemical Society (ACS)

Director: Ministerio de Ciencia e Innovación (Espanya)
Autor: Rosés Subirós, Cristina
Camó Marin, Cristina
Vogels, Kristy
Planas i Grabuleda, Marta
Feliu Soley, Lídia
Resum: The first solid-phase strategy for the synthesis of cyclic depsipeptides containing a phenyl ester linkage in their structure is described. The key steps of the synthesis were the formation of the phenyl ester bond and the on-resin head-to-side-chain cyclization. The amino acid configuration significantly influenced the formation and the stability of the cyclic depsipeptides. The presence of a l-Tyr1 and a d-Tyr7 led to the most stable sequences
This work was financed by Grant AGL2012-39880-C02-02
Accés al document: http://hdl.handle.net/2072/299088
Llenguatge: eng
Editor: American Chemical Society (ACS)
Drets: Tots els drets reservats
Matèria: Pèptids -- Síntesi
Peptides -- Synthesis
Depsipèptid
Depsipeptide
Títol: Solid-Phase Synthesis of Cyclic Depsipeptides Containing a Tyrosine Phenyl Ester Bond
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

Matèries


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