Ítem
| Ministerio de Ciencia e Innovación (Espanya) | |
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El Marrouni El Ghazaoui, Abdellatif
Heras i Corominas, Montserrat |
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The p-benzyloxybenzyloxy group is used to mask the oxo function of the 4(3H)-pyrimidinone ring in the synthesis of new unnatural amino acids. The synthetic approach is based on an aromatic nucleophilic substitution reaction between 4-[4-(benzyloxy)benzyloxy]-2-(benzylsulfonyl)pyrimidine and the nucleophilic side chain of several Nα-Boc amino esters, as the key step, followed by a series of standard protecting group transformations. p-Benzyloxybenzyloxy is efficiently removed under mild acid conditions to recover the 4(3H)-pyrimidinone system This work was supported by grants from the Spanish Ministerio de Economía y Competitividad (MINECO) (AGL2009-13255-C02-02/AGR and AGL2012-39880-C02-02) |
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| http://hdl.handle.net/2072/299089 | |
| eng | |
| Royal Society of Chemistry (RSC) | |
| Tots els drets reservats | |
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Aminoàcids -- Síntesi
Amino acids -- Synthesis |
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| Synthesis of new unnatural Nα-Fmoc pyrimidin-4-one amino acids: use of the p-benzyloxybenzyloxy group as a pyrimidinone masking group | |
| info:eu-repo/semantics/article | |
| Recercat |
