DUGi

Model Csp2-Csp3 Hurtley Coupling Catalysis that Operates through a Well-Defined CuI/CuIII Mechanism

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Hurtley-type coupling reactions, which were first discovered more than 80 years ago, involve the copper-catalyzed a-arylation of activated methylene compounds by using aryl halide substrates.[1–3] These reactions afford Csp2 Csp3 coupling products, usually as their a-aryl ketone derivatives. These compounds are important because they are found in a large number of natural products and they have also found wide application in pharmaceutical chemistry.[4] Importantly, there is not a clear understanding of the mechanistic details of copperbased Hurtley catalysis; therefore, unraveling the mechanistic pathways is of fundamental importance to facilitate the design of more-sustainable methodologie

We acknowledge financial support from the European Research Council for a Starting Grant Project to X.R. (ERC-2011-StG-277801), the MICINN of Spain (CTQ2009-08464/BQU to Dr. Costas and a PhD FPI grant to M.F.), the Consolider-Ingenio (CSD2010-00065), and the Catalan DIUE of the Generalitat de Catalunya (2009SGR637)

Wiley-VCH Verlag