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Sample preservation for the analysis of antibiotics in water

This paper describes a stability study performed for 56 antibiotics belonging to 9 different groups - macrolides, tetracyclines, fluoroquinolones, quinolones, penicillins, cephalosporines, lincosamides, sulfonamides and nitroimidazole antibiotics - in purified water samples fortified with the selected compounds at 10. ng/ml. For this purpose, three different sample preservation modes were tested with the aim of avoiding biotic and abiotic degradation: (i) storage at -20. °C, (ii) storage at -20. °C with 0.1% of EDTA and (iii) pre-concentration in a solid phase extraction cartridge (SPE), which was afterwards stored at -20. °C. Concentrations of antibiotics in the samples preserved using the different protocols were monitored after 0, 1, 2 and 12 weeks. The results showed that, for the accurate determination of all compounds they should be analyzed right after sampling. However, if this is not possible, most of the antibiotics can be analyzed within the 1st week after sampling and preservation at -20. °C (with or without EDTA) or in a SPE cartridges at -20. °C. Nonetheless, some antibiotics found extensively in the environment, such as sulfamethoxazole, ciprofloxacin, ofloxacin, erythromycin, azithromycin and clarithromycin exhibited low stability after 1 week preservation and, therefore, they should be analyzed within this time

Elsevier

Autor: Llorca, Marta
Gros, Meritxell
Rodríguez Mozaz, Sara
Barceló i Cullerés, Damià
Resum: This paper describes a stability study performed for 56 antibiotics belonging to 9 different groups - macrolides, tetracyclines, fluoroquinolones, quinolones, penicillins, cephalosporines, lincosamides, sulfonamides and nitroimidazole antibiotics - in purified water samples fortified with the selected compounds at 10. ng/ml. For this purpose, three different sample preservation modes were tested with the aim of avoiding biotic and abiotic degradation: (i) storage at -20. °C, (ii) storage at -20. °C with 0.1% of EDTA and (iii) pre-concentration in a solid phase extraction cartridge (SPE), which was afterwards stored at -20. °C. Concentrations of antibiotics in the samples preserved using the different protocols were monitored after 0, 1, 2 and 12 weeks. The results showed that, for the accurate determination of all compounds they should be analyzed right after sampling. However, if this is not possible, most of the antibiotics can be analyzed within the 1st week after sampling and preservation at -20. °C (with or without EDTA) or in a SPE cartridges at -20. °C. Nonetheless, some antibiotics found extensively in the environment, such as sulfamethoxazole, ciprofloxacin, ofloxacin, erythromycin, azithromycin and clarithromycin exhibited low stability after 1 week preservation and, therefore, they should be analyzed within this time
Accés al document: http://hdl.handle.net/2072/299817
Llenguatge: eng
Editor: Elsevier
Drets: Tots els drets reservats
Matèria: Contaminants emergents en l’aigua
Emerging contaminants in water
Cromatografia
Chromatographic analysis
Espectrometria de masses
Mass spectrometry
Aigua -- Contaminació
Water -- Pollution
Medicaments -- Aspectes ambientals
Drugs -- Environmental aspects
Títol: Sample preservation for the analysis of antibiotics in water
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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