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Smith Predictor Sliding Mode Closed-loop Glucose Controller in Type 1 Diabetes

Type 1 diabetic patients depend on external insulin delivery to keep their blood glucose within near-normal ranges. In this work, two robust closed-loop controllers for blood glucose regulation are developed to prevent the life-threatening hypoglycemia, as well as to avoid extended hyperglycemia. The proposed controllers are designed by using the sliding mode control technique in a Smith predictor structure. To improve meal disturbance rejection, a simple feedforward controller is added to inject meal-time insulin bolus. Simulations scenarios were used to test the controllers, and showed the controllers ability to maintain the glucose levels within the safe limits in the presence of errors in measurements, modeling and meal estimation

International Federation of Automatic Control

Author: Abu-Rmileh, Amjad Hisham Ahmad
García-Gabín, Winston
Date: 2018 June 5
Abstract: Type 1 diabetic patients depend on external insulin delivery to keep their blood glucose within near-normal ranges. In this work, two robust closed-loop controllers for blood glucose regulation are developed to prevent the life-threatening hypoglycemia, as well as to avoid extended hyperglycemia. The proposed controllers are designed by using the sliding mode control technique in a Smith predictor structure. To improve meal disturbance rejection, a simple feedforward controller is added to inject meal-time insulin bolus. Simulations scenarios were used to test the controllers, and showed the controllers ability to maintain the glucose levels within the safe limits in the presence of errors in measurements, modeling and meal estimation
Document access: http://hdl.handle.net/2072/320497
Language: eng
Publisher: International Federation of Automatic Control
Rights: Tots els drets reservats
Subject: Diabetis
Diabetes
Glucosa
Glucose
Pàncrees
Pancreas
Title: Smith Predictor Sliding Mode Closed-loop Glucose Controller in Type 1 Diabetes
Type: info:eu-repo/semantics/article
Repository: Recercat

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