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Prediction of glucose excursions under uncertain parameters and food intake in intensive insulin therapy for type 1 diabetes mellitus

Considering the difficulty in the insulin dosage selection and the problem of hyper- and hypoglycaemia episodes in type 1 diabetes, dosage-aid systems appear as tremendously helpful for these patients. A model-based approach to this problem must unavoidably consider uncertainty sources such as the large intra-patient variability and food intake. This work addresses the prediction of glycaemia for a given insulin therapy face to parametric and input uncertainty, by means of modal interval analysis. As result, a band containing all possible glucose excursions suffered by the patient for the given uncertainty is obtained. From it, a safer prediction of possible hyper- and hypoglycaemia episodes can be calculated

IEEE

Author: Calm i Puig, Remei
García Jaramillo, Maira Alejandra
Vehí, Josep
Bondía Company, Jorge
Tarin Sauer, Cristina
García-Gabín, Winston
Date: 2018 June 5
Abstract: Considering the difficulty in the insulin dosage selection and the problem of hyper- and hypoglycaemia episodes in type 1 diabetes, dosage-aid systems appear as tremendously helpful for these patients. A model-based approach to this problem must unavoidably consider uncertainty sources such as the large intra-patient variability and food intake. This work addresses the prediction of glycaemia for a given insulin therapy face to parametric and input uncertainty, by means of modal interval analysis. As result, a band containing all possible glucose excursions suffered by the patient for the given uncertainty is obtained. From it, a safer prediction of possible hyper- and hypoglycaemia episodes can be calculated
Document access: http://hdl.handle.net/2072/320582
Language: eng
Publisher: IEEE
Rights: Tots els drets reservats
Subject: Control predictiu
Diabetis
Glucèmia
Insulina -- Ús terapèutic
Blood sugar
Diabetes
Insulin -- Therapeutic use
Predictive control
Title: Prediction of glucose excursions under uncertain parameters and food intake in intensive insulin therapy for type 1 diabetes mellitus
Type: info:eu-repo/semantics/article
Repository: Recercat

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