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DUGi: Ítem | Recercat - An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

Ítem


An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies

A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells

Royal Society of Chemistry (RSC)

Autor: Gandioso, Albert
Shaili, Evyenia
Massaguer i Vall-llovera, Anna
Artigas, Gerard
González-Cantó, Alejandro
Woods, Julie A.
Sadler, Evyenia
Marchán, Vicente
Data: 5 juny 2018
Resum: A new anticancer agent based on the conjugation of a photoactivatable Pt(iv) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells
Accés al document: http://hdl.handle.net/2072/320976
Llenguatge: eng
Editor: Royal Society of Chemistry (RSC)
Drets: Attribution 3.0 Spain
URI Drets: http://creativecommons.org/licenses/by/3.0/es/
Matèria: Medicaments antineoplàstics
Antineoplastic agents
Títol: An integrin-targeted photoactivatable Pt(iv) complex as a selective anticancer pro-drug: Synthesis and photoactivation studies
Tipus: info:eu-repo/semantics/article
Repositori: Recercat

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