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Proportionality: A Valid Alternative to Correlation for Relative Data

In the life sciences, many measurement methods yield only the relative abundances of different components in a sample. With such relative-or compositional-data, differential expression needs careful interpretation, and correlation-a statistical workhorse for analyzing pairwise relationships-is an inappropriate measure of association. Using yeast gene expression data we show how correlation can be misleading and present proportionality as a valid alternative for relative data. We show how the strength of proportionality between two variables can be meaningfully and interpretably described by a new statistic. which can be used instead of correlation as the basis of familiar analyses and visualisation methods, including co-expression networks and clustered heatmaps. While the main aim of this study is to present proportionality as a means to analyse relative data, it also raises intriguing questions about the molecular mechanisms underlying the proportional regulation of a range of yeast genes

DL was funded by the Commonwealth Scientific and Industrial Research Organisation (www.csiro.au). VPG was funded by the Spanish Ministry of Education, Culture and Sports under a Salvador de Madariaga grant (Ref. PR2011-0290) and by the Spanish Ministry of Economy and Competitiveness under the project METRICS Ref. MTM2012-33236. JJE was funded by the Agencia de Gestio d’Ajuts Universitaris i de Recerca of the Generalitat de Catalunya under project Ref: 2009SGR424. SM was funded by the UK Medical Research Council. JB was funded by a Wellcome Trust Senior Investigator Award (grant #095598/Z/11/Z)

PLoS Computational Biology, 2015, vol. 11, núm. 3, p. UNSP e1004075

Public Library of Science (PLoS)

Author: Lovell, David
Pawlowsky-Glahn, Vera
Egozcue, Juan José
Marguerat, Samuel
Bähler, Jürg
Date: 2015 March 16
Abstract: In the life sciences, many measurement methods yield only the relative abundances of different components in a sample. With such relative-or compositional-data, differential expression needs careful interpretation, and correlation-a statistical workhorse for analyzing pairwise relationships-is an inappropriate measure of association. Using yeast gene expression data we show how correlation can be misleading and present proportionality as a valid alternative for relative data. We show how the strength of proportionality between two variables can be meaningfully and interpretably described by a new statistic. which can be used instead of correlation as the basis of familiar analyses and visualisation methods, including co-expression networks and clustered heatmaps. While the main aim of this study is to present proportionality as a means to analyse relative data, it also raises intriguing questions about the molecular mechanisms underlying the proportional regulation of a range of yeast genes
DL was funded by the Commonwealth Scientific and Industrial Research Organisation (www.csiro.au). VPG was funded by the Spanish Ministry of Education, Culture and Sports under a Salvador de Madariaga grant (Ref. PR2011-0290) and by the Spanish Ministry of Economy and Competitiveness under the project METRICS Ref. MTM2012-33236. JJE was funded by the Agencia de Gestio d’Ajuts Universitaris i de Recerca of the Generalitat de Catalunya under project Ref: 2009SGR424. SM was funded by the UK Medical Research Council. JB was funded by a Wellcome Trust Senior Investigator Award (grant #095598/Z/11/Z)
Format: application/pdf
ISSN: 1553-734X (versió paper)
1553-7358 (versió electrònica)
Document access: http://hdl.handle.net/10256/10927
Language: eng
Publisher: Public Library of Science (PLoS)
Collection: MINECO/PN 2013-2015/MTM2012-33236
AGAUR/2009-2014/2009 SGR-424
Reproducció digital del document publicat a: http://dx.doi.org/10.1371/journal.pcbi.1004075
Articles publicats (D-IMA)
Is part of: PLoS Computational Biology, 2015, vol. 11, núm. 3, p. UNSP e1004075
Rights: Attribution 3.0 Spain
Rights URI: http://creativecommons.org/licenses/by/3.0/es/
Subject: Correlació (Estadística)
Correlation (Statistics)
Probabilitats
Probabilities)
Mostreig (Estadística)
Sampling (Statistics)
Expressió gènica -- Mètodes estadístics
Gene expression -- Statistical methods
Title: Proportionality: A Valid Alternative to Correlation for Relative Data
Type: info:eu-repo/semantics/article
Repository: DUGiDocs

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